74.Telithromycin產生膽鹼拮抗作用,與結構中下列何種基團有關?
(A)piperidine
(B)pyridine
(C)pyrrolidine
(D)pyrimidine
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統計: A(715), B(1632), C(1830), D(856), E(0) #2756098
統計: A(715), B(1632), C(1830), D(856), E(0) #2756098
詳解 (共 6 筆)
#6014321
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.

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