9. Uncoupling of mitochondrial oxidative phosphorylation: (A) Allows continued mitochondrial ATP formation, but halts O2 consumption. (B) Halts all mitochondrial metabolism. (C) Halts mitochondrial ATP formation, but allows continued O2 consumption. (D) Slows down the citric acid cycle. (E) Slows the conversion of glucose to pyruvate by glycolysis.

1. Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship. In eachcase, the single intermediate is the ES complex.Free energy, (A) Diagram (a) describes a strict "lock and key" model, whereas diagram (b) describes a transition-state complementarity model. (B) The activation energy for the catalyzed reaction is #5 in diagram (a) and is #7 in diagram (b). (C) The activation energy for the uncatalyzed reaction is given by #5 + #6 in diagram (a) and by #7 + #4 in diagram (b). (D) The contribution of binding energy is given by #5 in diagram (a) and by #7 in diagram (b). (E) The ES complex is given by #2 in diagram (a) and #3 in diagram (b).

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