1. For RNA polymerase II, the general transcription factor TFIIA not only can (1) stabilize TBP-TATA box binding, but also (2) stimulate TFIID-promoter binding. Please explain this mechanism of anti-repression.

5. David would like to design an expression construct that allows expressions of green fluorescent protein (GFP) and coronavirus spike (S) protein from one single RNA in 293T cells. Please draw a map of this construct and provide the rationale of the construct design, e.g., explain the function of each critical component on this map.

1. For RNA polymerase II, the general transcription factor TFIIA not only can (1) stabilize TBP-TATA box binding, but also (2) stimulate TFIID-promoter binding. Please explain this mechanism of anti-repression.

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