申論題

9. In 2012, the Nobel Prize in Physiology / Medicine was awarded jointly to Sir John Gurdon and Shinya Yamanaka. The "Yamanaka factors" - Sox2, Oct4, Klf4, and c-Myc - were identified in a screen. Describe how one may carry out such screen (using the following terms: transcriptional factors, mature cells, pluripotency markers, and so on). (7 points)