2. Entresto is used for heart failure treatment. Which is not the action mechanism of entresto?
(A) Inhibit neprelysin by sacubitril
(B) Inhibit AT1 receptor by valsartan
(C) Inhibit neprelysin by LBQ657
(D) Activate AT2 receptor by irbesartan

3. Which of the following descriptions about sodium channel blockers is incorrect? (A) Lidocaine, a local anesthetics, can block sodium channel. (B)Tetrodotoxin(河豚毒素)is a pore blocker of sodium channel. (C) Phenytoin, an anti-epileptic drug, is a pore blocker of sodium channel. (D) Carbamazepinc, an anti-cpileptic drug, is a usc-dependent blocker of sodium channel.

4. Which of the following descriptions about receptor binding drugs is incorrect? (A) a-Bungarotoxin, a kind of snake poison, is an antagonist of GABA receptor. (B) Caffeine is an antagonist of adenosine receptor. (C) Ketamine is a NMDA neurotransmitter blocker. (D) Ondansetron, an antiemetics (止吐藥), is a serotonin receptor agonist.

5. Which of the following descriptions about neuronal action potential is incorrect? (A) It requires sodium channel and potassium channel to work together. (B) When sodium channel opens, it depolarizes the neuronal membrane and promotes potassium channel opening. (C) Sodium channel opens faster than potassium channel. (D) Sodium channel requires potassium channel to close.

6. Which of the following descriptions about tricyclic antidepressant (TCA) is incorreet? (A) It inhibits the reuptake of serotonin at the presynaptic site. (B) It inhibits the reuptake of norepinephrine at the presynaptic site. (C) A common side effect of TCA is dry mouth. (D) It suppresses the degradation of monoamine at the presynaptic site.

7. Which of the following descriptions about thyroid related drugs is incorrect? (A) In patients with hypothyroidism, thyroxine (T4) supplement is a therapeutic option. (B) Radioactive iodine () can destroy thyroid gland because it accumulates in the thyroid stromal cell itself. (C) Propylthiouracil (PTU) is a drug for hyperthyroidism that inhibits thyroid hormone synthesis by inhibiting thyroid peroxidase. (D) Thiocyanate is a drug for hyperthyroidism that inhibits sodium-iodine symporter.

8.下列有關抗瘧疾藥的敘述,何者正確?(A)Chloroquine 無法殺死紅血球中的症原蟲。(B)Quinine無法殺死紅血球中的瘧原蟲。(C)Primaquine 無法殺死紅血球中的原蟲(D)以上皆是

9.下列有關寄生蟲藥物的敘述·何者正確?(A)Abendazole 可以殺死所有的寄生蟲。(B)Abendazole的作用機轉是結合beta-tubulin,抑制微小管(microtubule)之聚合作用。(C)Abendazole 必须要和Praziquantel 併用(D)praziquantel的作用機轉是抑制有calcium進入寄生蟲的细胞,造成蟲體癱軟而被排出。

10.下列有關selective serotonin reuptake inhibitor(SSRI)的說明,何者錯誤?(A) SSRI常被作為抗憂鬱藥使用。(B) SSRI 一般在個小時內,就能發揮藥效。(C) SSRI的其中一個副作用,是體內有太多serotonin,產生sotosto(D)SSRI不能和monoamine oxidase inhibitor(MAOI併併用,可能會出現 malignant hypertension.

() 1. Aspirin could be used to stop heparin-induced intestinal bleeding.(A)O(B)X

()2. Ketorolac could be used to treat chronic renal failure.(A)O(B)X

110年 - 110 國立臺灣大學_碩士班招生考試_部分系所:藥理學#102017

110年 - 110長庚大學_碩士班招生考試_生物醫學研究所︰藥理學#101173