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99年 - 學士後西醫化學99化學#36021

科目：學士後西醫-化學 | 年份：99年 | 選擇題數：80 | 申論題數：0

試卷資訊

所屬科目：學士後西醫-化學

選擇題 (80)

1. About the ionic liquids, which statement is true? (A) They dissolve both polar and nonpolar organic compounds. (B) They are nonflammable. (C) They are thermally stable. (D) They do not evaporate. (E) All in the above.
2. When an SN2 reaction was carried out, under which of the following solvents would you expect acetate ion  to be the most reactive nucleophile? (A) DMSO (B) DMF (C) THF (D) CH3OH (E) H2O
3. What is the energy difference in kcal/mol between cis-1,2-dimethylcyclohexane and its trans isomer? (A) 0 (B) 0.9 (C) 1.8 (D) 2.7 (E) 3.6
4. Dieldrin, C12H8Cl6O, is a pentacyclic compound formerly used as an insecticide. How many double bonds does dieldrin have? (A) 1 (B) 2 (C) 3 (D) 4 (E) 5
5. Which of the following is not a major peak in the Mass spectrum of isopentane? (A) 29 (B) 43 (C) 57 (D) 60 (E) 72
6. Which of the following compounds is the least reactive toward nucleophilic acyl substitution? (
7. When compared to the keto form, the enol form of which of the following compounds is most stable? 
8. Among the butane conformers, which occur at energy minima on a graph of potential energy versus dihedral angle? (A) gauche only (B) eclipsed and totally eclipsed (C) gauche and anti (D) eclipsed only (E) anti only
9. Rank the following amines in order of decreasing basicity. (A) I > II > III > IV (B) II > I > III > IV (C) III > I > II > IV (D) IV > I > III > II (E) I > III > II > IV
10. Which of the following compounds has the highest boiling point? (A) CH3CH2CH2OH (B) CH3CO2CH3 (C) CH3CH2CO2H (D) CH3CH2CH2CONH2 (E) CH3CH2CN
11. In the following alkanes, which one has the lowest strain energy? (A) cylopropane (B) cyclobutane (C) cyclohexane (D) cycloheptane (E) cyclooctane
12. Which of the following compounds has the greatest dipole moment? phpLVnPnG
13. Which of the following acids has the greatest rate toward decarboxylation? 

14. Which of the following structures is chiral? (A)(B)(C)(D)(E) none of above

15. Which of the following molecular orbitals is the HOMO of 1,3-butadiene in the ground state? 
16. Which of the following species has the greatest λmax in the UV spectrum? 
17. Which of the following compounds absorbs the longest wavelength of UV-visible light? 
18. Which of the following solvents is best used in IR spectrum? (A) water (B) ether (C) CCl4 (D) THF (E) methanol
19. Which of the following esters has the highest frequency of the C=O absorption? 
20. Using a 60 MHz spectrometer, a chemist observes the following absorption: doublet, J = 7.0 Hz, at δ 4.00. What would the chemical shift (δ) be in the 300 MHz spectrum? (A) 3.50 (B) 4.00 (C) 4.50 (D) 20.0 (E) 0.80
21. How many types of nonequivalent protons of the following compounds are possible? (A) 4 (B) 5 (C) 6 (D) 7 (E) 8
22. The major type of reactions that alkanes undergo is: (A) electrophilic substitution reactions. (B) electrophilic addition reactions (C) free radical substitution reactions (D) free radical addition reactions (E) nucleophilic substitution reactions
23. What is the following name reaction? (A) Friedel-Crafts alkylation (B) Friedel-Crafts allylation (C) Claisen rearrangement (D) Ritter reaction (E) Curtius rearrangement
24. What is the following reaction? (A) aldol condensation (B) Cannizzaro reaction (C) Claisen-Schmidt reaction (D) Knoevenagel reaction (E) Wittig reaction
25. What product will be given if indole is reacted with bromine at 0 oC in dioxane? (A) 2-bromoindole (B) 3-bromoindole (C) 4-bromoindole (D) 5-bromoindole (E) none of the above
26. Which of the following alkenes has the greatest reactivity toward ozonolysis? 
27. What is the major product of the reaction shown below?
(A)(B)(C)(D)(E) all of the above 
28. Bextra, a COX-2 inhibitor used in the treatment of arthritis, contains a heterocyclic ring. What is this heterocyclic ring named? (A) furan ring (B) oxazole ring (C) isoxazole ring (D) thiophene ring (E) indole ring

29. Which of the following halides has the greatest rate toward nucleophilic aromatic substitution? (A)(B)(C)(D)(E) they all have the same rate

30. Provide the major product in the oxidation of n-butylbenzene with KMnO4.
31. Which of the following diols cannot be cleaved by periodic acid? 
32. A primary kinetic isotope effect could most likely to be observed in which of the following mechanisms? (A) SN1 and SN2 (B) SN2 (C) E1 and SN1 (D) E2 (E) E1
33. Rank the following compounds in an order of decreasing rate in an E2 reaction. (A) A > B > C (B) A > C > B (C) B > A > C (D) C > A > B (E) C > B > A
34. Provide the structure of the major product which results in the following reaction. 
(A)(B)(C)(D)(E) no reaction
35. Provide the organic product(s) of the reaction shown below. (A)Ⅰ (B) Ⅱ (C) Ⅲ (D) Ⅰ and Ⅱ (E) Ⅰ and Ⅲ
36. What is the major product of the following reaction? (A) 4-ethyl-2,3-dimethyl-2-propylpyridine (B) 5-ethyl-2,3-dimethyl-2-propylpyridine (C) 6-ethyl-2,3-dimethyl-2-propylpyridine (D) 2-methyl-3-propylpyridine (E) 3-methyl-2-propylpyridine
37. What is the major product of the following reaction? 
(A)(B)(C)(D)(E) none of the above 
38. Provide reagents to complete the following reaction. (A) DEAD, PPh3 (B) H2SO4 (C) NaOH (D) DMSO, oxalyl chloride (E) Bu3SnH
39. The final product would you expect from the following sequential reactions from p-toluidine. (A) 2-bromo-3-methylaniline (B) 3-bromo-4-methylaniline (C) 2-bromo-4-methylaniline (D) 2-bromo-4-methylphenol (E) none of the above
40. What is the major product of the following reaction sequence? 
41. What is the major product of the following reaction? 
42. What is the major product of the following reaction? 
43. What is the major product of the following reaction? 
44. What is the major product from the following reaction?
45. What product would be obtained from the following reaction? 
46. What will be the product of the following transformations? 
47. What is the major product of the following transformations?
(A)(B)(C)(D)(E) none of the above
48. Provide the organic product of the reaction shown below. 
49. What is the final product of the following sequential reactions? 
50. What is the product of the following reaction sequence? 
51. What is the final major product of the following transformations? 
52. Which of the following reaction conditions could not be used in the following transformation?
(A)(B)(C)(D)(E) none of the above
53. What product will be formed by the following reaction conditions? 
54. Which one is the kinetic product of the following reaction? 
55. Which of the following reagents should be used to convert methyl hexanoate to hexanal?(A)(B)(C)(D)(E)
56. Which of the following reagents should be used for the following transformaton? (A) LiAlH4 then H3O+ (B) NaBH4 then H3O+ (C) [(CH3)2CHCH2]2AlH, -78o C then H2O (D) LiAlH[OC(CH3)3]3, -78o C then H2O (E) BH3‧THF then H2O
57. What is the major product of the following reaction? 
58. What is the major product of the following reaction? (A) 2,2-dimethyl-3-phenylpropanoic acid (B) 2,2-dimethyl-3-chloro-3-phenylpropanoic acid (C) 2,2-dimethyl-3-chloro-3-(2-chloro)phenylpropanoic acid (D) phetermine (E) none of the above
59. What reagents are used to dehydrate amides to nitriles? I.P2O5  IIPOCl3   IIISOCl2(A)Ⅰ (B)Ⅱ (C)Ⅲ (D)Ⅰ and  Ⅱ (E) all of the above
60. What is the named reaction of the following coupling reaction? (A) Grignard reaction (B) Gilman reaction (C) Stille reaction (D) Heck reaction (E) Suzuki reaction 
【單選題】每題 2 分，共計 40 分，答錯 1 題倒扣 0.5 分，倒扣至本大題零分為止，未作答，不給分亦不扣分。
61. Predict the number of carbon resonance lines you would expect in the 13C-NMR spectra of ethyl acrylate. (A) 2 (B) 3 (C) 4 (D) 5 (E) 6
62. What organic product would you expect from the following reaction? 
63. Which of the following reactions is called Perkin condensation? (A) (B)  (C) (D) (E) none of the above
64. What is the major product for the following reaction? 
65. What is the major product of the following reaction? 
66. Provide the final product of the following reaction. 
67. What is the final product of the following sequential reactions? 
68. What is the major product of the following reaction sequence? 
69. What is the product of the following reaction sequence? 
70. Which of the following compounds will not undergo a ring-opening reaction under thermal conditions? (A) Ⅰ only (B) Ⅱ only (C) Ⅲ only (D) Ⅰ and Ⅱ (E) Ⅰ and Ⅲ
71. What is the major product of the following reaction? (A) Ⅰ (B) Ⅱ (C)Ⅰ and  Ⅲ (D) Ⅳ (E) Ⅴ
72. Provide the final product of the following reaction.
73. Provide the final product of the following reaction. 
74. Provide the final product of the following reaction. 
75. What is the major product of the following reaction? 
76. What is the major product of the following reaction? 
77. Provide the major organic product of the reaction shown below. (A) (B) (C) (D) (E)
78. What is the major product of the following reaction under thermal conditions? 
79. Provide the final product of the following reactions.
80. What is the major product of the following reactions? 

申論題 (0)