(5) Which of the followings is most likely to lead to a loss of gene function?
(A) A missense mutation in the open reading frame
(B) A frameshift mutation in the coding region
(C) A change from a T to C in the promoter region
(D) A change from a TAA codon to a TAG codon in the coding region
(E) A sequence change in the 3' untranslated region
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