試題詳解

30. Which of the following descriptions regarding signal transduction downstream of GPCR is (are) CORRECT?
(A) Adenylyl cyclase, which produces cyclic AMP, is a direct target of G protein
(B) GPCR may induce depolarization of neuronal membrane by activating cyclic nucleotide-gated channels (CNG)
(C) Cyclic AMP activates protein kinase A (PKA) by promoting the association of the PKA catalytic subunits with the PKA regulatory subunits
(D) G protein may activate phospholipase C, which in turn catalyzes the production of diacylglycerol (DG) and inositol 1,4,5-triphosphate (IP3)
(E) G protein may activate or inhibit adenylyl cyclase, and this property of G protein is determined by the By-subunit