1. All are correct about enhancer sequences in eukaryotic cells except:
(A) they can oce cur cither upstream or downstream of the gene.
(B) they can be in either oricntation (bi-directional).
(C) enhancer function is dependent on recognition by a specific transcription factor.
(D) specific tran inscription factor binding at an enhancer stimulates transcription by interacting with RNA polymerase II.
(E) All are correct.