10. Which is incorrect about transcription activators (or sequence-specific DNA-binding proteins) in eukaryotic cells?
(A) They contain DNA-binding domain and activation domain.
(B) They bind to enhancers.
(C) They interact with Mediators through activation domain.
(D) Their binding elements need to next to promoter for recruit RNA polymerase.
(E) They play key roles in control the transcription rate.

6. Which of the following is not part of RNA processing in eukaryotes? (A) Addition of a 5'cap (B) Addition of a polyA. tail (C) Intron removal (D) Splicing of exons (E) Reverse transcription

7. Cellular iron homeostasis is accomplished by the coordinated regulated expression of the transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. There are iron responsive element (IRE) in the 5' UTR of ferritin mRNA and in the3' UTR of transferrin receptor mRNA. (1) IRE-binding proteins bind to IREs of ferritin mRNA to inhibit translation in lower iron concentration；  (2) IRE-binding proteins bind to IREs of ferritin mRNA to inhibit translation in higher iron concentration； (3) IRE-binding proteins bind to IREs of transferrin receptor mRNA to stabilize mRNA in lower iron concentration； (4) IRE-binding proteins bind to IREs of transferrin receptor mRNA to stabilize mRNA in higher iron concentration. Which are correct? (A) (1) and (3) (B) (2) and (4) (C) (1) and (4) (D) (2) and (4) (E) all are incorrect

8. The following: (1). histone acetylation； (2). H3K4me (histone3 lysine4 methylation)； (3).H3K9me (histone3 lysine9 methylation)； (4).H3K27me (histone 3 lysine 27 methylation)； (5). DNA methylation； (6). HDAC (histone deacetylase)； (7). HAT (histone acetyltransferase). Which are related to gene activation? (A) (1), (2) and (7) (B) (1), (3), (4) and (6) (C) (1), (2), (3), (4), (5) and (6) (D) (3), (4), (5) and (6) (E) (1) and (7)

9. In prokaryotes, protein synthesis rates are limited by the rates of mRNA synthesis. RNA synthesis occurs at about 60 nucleotides/sec. Therefore, protein synthesis occurs at about amino acids/sec. (A) 10 (B) 15 (C) 20 (D) 30 (E) 60

11. Which one is the product of cytosine deamination? (A) Adenine (B) Guanine (C) Inosine (D) Xanthine (E) Uracil

12. The protein which marks proteins for degradation is called . (A) Chaperonin (B) Ubiquitin (C) Proteosomin (D) Apoptosin (E) adenosine

13. Which one is NOT a programmed cell death? (A) Apoptosis (B) Necroptosis (C) Necrosis (D) Pyroptosis (E) Phagoptosis

複選題14. The central dogma does not include (A) DNA replication (B) RNA transcription (C) Protein translation (D) Reverse transcription (E) Lysine sumoylation

15. Which one is NOT an unfolded protein response? (A) endocytosis (B) Increase chaperon protein expression (C) Promote protein degradation (D) Induce apoptosis (E) Autophagy

16. Indicate which process NOT requires membrane fusion? (A) Insulin-mediated blood glucose homeostasis (B) Virus infection (C) Cholesterol endocytosis (D) Brain computation (E) Muscle contraction induced by nerve stimulation