阿摩線上測驗
15.下列那兩種藥品在slow acetylators，容易引起類狼瘡症候群（lupus-like syndrome）？ ①aspirin
②hydralazine ③procainamide ④prednisolone
(A)①②
(B)②③
(C)③④
(D)①④
答案：登入後查看
統計： A(268), B(4651), C(37), D(12), E(0) #1742744
統計： A(268), B(4651), C(37), D(12), E(0) #1742744
詳解 (共 9 筆)
Aurora737
#2929587
紅斑性狼瘡禁用：
Hydralazine
Procainamide
Isoniazide(INH)
Propylthiouracil(PTU)
219
1
Jumpjump
#2916011
Isoniazid SE：lupus-like syndrome
23
1
神奇地瓜泥
#4881020
The risk of drug-induced lupus varies across different medications. Drug-induced lupus-associated drugs have been classified as having a high (>5 percent), moderate (1 to 5 percent), low (0.1 to 1 percent), or very low (approximately 0.1 percent) risk of inducing drug-induced lupus [6,21,22].
●High risk – Drugs that have been associated with the highest risk of inducing drug-induced lupus in an individual patient include procainamide (15 to 20 percent incidence per year) [2] and hydralazine (5 to 10 percent incidence per year) [9].
●Moderate risk – Quinidine has been associated with a moderate risk of drug-induced lupus [23].
●Low risk – Drugs thought to be associated with a low risk include penicillamine, carbamazepine, methyldopa, sulfasalazine, minocycline, chlorpromazine, propylthiouracil, and isoniazid [24-27].
●Very low risk – Drugs associated with very low risk include statins (atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin) [28-30] and tumor necrosis factor (TNF) inhibitors (infliximab, etanercept adalimumab, golimumab, certolizumab) [31-35], as well as a variety of other miscellaneous drugs (isopropamide, propafenone, atenolol, clonidine, enalapril, labetalol, minoxidil, pindolol, prazosin, chlorpromazine, lithium carbonate, phenelzine, nitrofurantoin, ethosuximide, phenytoin, primidone, trimethadione, phenylbutazone, chlorthalidone, aminoglutethimide, levodopa, ophthalmic timolol, interferon alfa, and interleukin [IL] 2) [6].
●High risk – Drugs that have been associated with the highest risk of inducing drug-induced lupus in an individual patient include procainamide (15 to 20 percent incidence per year) [2] and hydralazine (5 to 10 percent incidence per year) [9].
●Moderate risk – Quinidine has been associated with a moderate risk of drug-induced lupus [23].
●Low risk – Drugs thought to be associated with a low risk include penicillamine, carbamazepine, methyldopa, sulfasalazine, minocycline, chlorpromazine, propylthiouracil, and isoniazid [24-27].
●Very low risk – Drugs associated with very low risk include statins (atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin) [28-30] and tumor necrosis factor (TNF) inhibitors (infliximab, etanercept adalimumab, golimumab, certolizumab) [31-35], as well as a variety of other miscellaneous drugs (isopropamide, propafenone, atenolol, clonidine, enalapril, labetalol, minoxidil, pindolol, prazosin, chlorpromazine, lithium carbonate, phenelzine, nitrofurantoin, ethosuximide, phenytoin, primidone, trimethadione, phenylbutazone, chlorthalidone, aminoglutethimide, levodopa, ophthalmic timolol, interferon alfa, and interleukin [IL] 2) [6].
These drugs and others have also been classified in terms of probability of causing drug-induced lupus [6,15,16,21,38-42]:
●Definite – Medications identified as definitely causing drug-induced lupus include procainamide, hydralazine, minocycline, penicillamine, isoniazid, quinidine, anti-TNF therapy (most commonly with infliximab and etanercept), interferon alfa, methyldopa, chlorpromazine, and practolol [40,43,44].
●Probable – Medications identified as probable causes of drug-induced lupus include anticonvulsants (phenytoin, mephenytoin, trimethadione, ethosuximide, carbamazepine), antithyroid drugs, antimicrobial agents (sulfonamides, rifampin [45], nitrofurantoin), beta blockers, lithium, paraaminosalicylate, captopril, interferon gamma, hydrochlorothiazide, glyburide, sulfasalazine, terbinafine, amiodarone, ticlopidine, and docetaxel [43,45-50].
●Possible – Medications that are possible causes of drug-induced lupus include gold salts, penicillin, tetracycline, reserpine, valproate, statins (eg, lovastatin, simvastatin, and atorvastatin), griseofulvin, gemfibrozil, valproate, lamotrigine, ophthalmic timolol, and 5-aminosalicylate.
●Definite – Medications identified as definitely causing drug-induced lupus include procainamide, hydralazine, minocycline, penicillamine, isoniazid, quinidine, anti-TNF therapy (most commonly with infliximab and etanercept), interferon alfa, methyldopa, chlorpromazine, and practolol [40,43,44].
●Probable – Medications identified as probable causes of drug-induced lupus include anticonvulsants (phenytoin, mephenytoin, trimethadione, ethosuximide, carbamazepine), antithyroid drugs, antimicrobial agents (sulfonamides, rifampin [45], nitrofurantoin), beta blockers, lithium, paraaminosalicylate, captopril, interferon gamma, hydrochlorothiazide, glyburide, sulfasalazine, terbinafine, amiodarone, ticlopidine, and docetaxel [43,45-50].
●Possible – Medications that are possible causes of drug-induced lupus include gold salts, penicillin, tetracycline, reserpine, valproate, statins (eg, lovastatin, simvastatin, and atorvastatin), griseofulvin, gemfibrozil, valproate, lamotrigine, ophthalmic timolol, and 5-aminosalicylate.
不同藥物風險供參
ref uptodate drug-induced lupus
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