15. What role does adenylate cyclase play in signal transduction? (A) Activates phospholipase C (B) Converts ATP to cAMP (C) Produces IPs and DAG from phosphatidylinositol 4,5-bisphosphate (PIP2) (D) Activates protein kinase A directly (E) Converts GTP to GDP

1. Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship. In eachcase, the single intermediate is the ES complex.Free energy, (A) Diagram (a) describes a strict "lock and key" model, whereas diagram (b) describes a transition-state complementarity model. (B) The activation energy for the catalyzed reaction is #5 in diagram (a) and is #7 in diagram (b). (C) The activation energy for the uncatalyzed reaction is given by #5 + #6 in diagram (a) and by #7 + #4 in diagram (b). (D) The contribution of binding energy is given by #5 in diagram (a) and by #7 in diagram (b). (E) The ES complex is given by #2 in diagram (a) and #3 in diagram (b).

15. What role does adenylate cyclase play in signal transduction?
(A) Activates phospholipase C
(B) Converts ATP to cAMP
(C) Produces IPs and DAG from phosphatidylinositol 4,5-bisphosphate (PIP₂)
(D) Activates protein kinase A directly
(E) Converts GTP to GDP

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