16. Active transport is transport ______. (A) of all molecules simultaneously, against their concentration gradients, across the membrane (B) in an energetically favorable direction coupled to the hydrolysis of ATP (C) in an energetically unfavorable direction always driven by hydrolysis of ATP (D) in an energetically unfavorable direction always coupled to another reaction or source of energy (E) in an energetically unfavorable direction driven only by the flow of another molecule across a membrane