17. Which one of the following statement is wrong? (A)The spinal cord and brainstem nuclei are home to second-order neurons, the first step of central nervous system (CNS) processing. (B) A proto-oncogene, c-fos, is activated after potentially tissue-damaging stimuli are applied to most tissues. (C) A systematic comparison study of Fos and pERK as markers of spinal nociceptive activation revealed greater specificity for activity in nociceptive pathways (vs. non-nociceptive activation) using Fos. (D) The spinal cord is segregated into areas that, on gross examination, appear as white and grey matter and consist of predominantly myelinated nerve fiber tracts and cell bodies, respectively. (E) Using Rexed’s cytoarchitecture-based classification system, there are at least 10 different layers or laminae of neurons—of which the first six (I to VI) are termed the dorsal horn of the spinal cord .