21.下列何者之sedation、dry mouth、urinary retension等副作用最顯著？
(A)promethazine
(B)cetirizine
(C)fexofenadine
(D)desloratadine

補充：

Astemizole

Terfenadine

兩者具有心毒性  

第一代

CLASS Ethylenediamines：

1. Mepyramine
2. Chloropyramine
3. Antazoline
4. Tripelennamine

CLASS Ethanolamines

1. Diphenhydramine(治療鼻炎,動暈症,或助眠效果等。其止咳效果來自於對延腦的咳嗽抑制)
2. Carbinoxamine
3. Doxylamine
4. Orphenadrine
5. Bromazine
6. Clemastine
7. Dimenhydrinate

CLASS Alkylamines

1. Pheniramine
2. Chlorphenamine(Chlorpheniramine)
3. Dexchlorpheniramine
4. Dexbrompheniramine
5. Brompheniramine
6. Triprolidine(Anticholinergic)
7. Dimetindene

CLASS Piperazines

1. Cyclizine
2. Chlorcyclizine
3. Hydroxyzine
4. Meclizine（抗膽鹼）

CLASS Tricyclics and Tetracyclics

1. Promethazine
2. Alimemazine
3. Cyproheptadine（橘橘的）
4. Azatadine

第二代

1. Loratadine
2. Fexofenadine
3. Cetirizine
4. Acrivastine
5. Azelastine(also topical): first line鼻炎medicine
6. Bilastine
7. Astemizole
8. Ketotifen
9. Rupatadine
10. Mizolastine
11. Ebastine
12. Bepotastine
13. Terfenadine
14. Quifenadine
15. Levocabastine(Topical)
16. Olopatadine(Topical)

第三代

1. Desloratadine
2. Levocetirizine
3. Fexofenadine