22. Please identify the major E2 elimination product of the following compound. t-Bu (A)(B)(C)(D)(E)

2. Physostigmine is used in the treatment of glaucoma. Within this structure, the atom indicated by is most basic, while atom is least basic. (A) 1 (most basic), 4 (least basic) (B) 1 (most basic), 3 (least basic) (C) 2 (most basic), 4 (least basic) (D) 2 (most basic), 3 (least basic) (E) None of the above.