25. Which of the following statement(s) is correct regarding to intracellular protein trafficking?
(1) Vesicular transport is tightly regulated by small GTPase that cycles between GDP-bound and GTP-bound state.
(2) COPII vesicles transport proteins from ER to Golgi while COPI vesicles transport proteins from Golgi to the plasma membrane.
(3) Membrane fusion step is driven by GTP hydrolysis for the dissociation of SNARE protein complexes.
(A) 1 only
(B) 1 and 2
(C) 1 and 3
(D) 2 and 3
(E) All of above are correct.