試題詳解

35. Which of the following description for the analgesic pharmacology in infants and children is wrong?
(A) Neonates and young children have increased maturation of hepatic enzymes involved in the metabolism of analgesics such as opioids and amide local anesthetics
(B) Neonates and young infants have decreased plasma concentrations of albumin and α1 acid glycoprotein, leading to decreased protein binding and greater concentrations of unbound, pharmacologically active drug
(C) Neonates also have reduced glomerular filtration rates in the first few weeks of life resulting in slower elimination of many drugs
(D) Young infants have significantly less of pseudocholinesterase compared to the adult population, leading to prolonged clearance of the ester-type local anesthetics
(E) all of the above are correct descriptions