35. Which of the following is true about medullary carcinoma of the colon?
(A) It accounts for 20% of colorectal carcinomas
(B) It is poorly differentiated, with a poor prognosis
(C) It most often arises in elderly women
(D) It usually arises in the rectosigmoid

31. 下列有關唾液腺腫瘤與其常見分子變化之配對，何者錯誤？ (A) Pleomorphic adenoma：EWSR1-ATF1 fusion。 (B) Mucoepidermoid carcinoma：CRTC1-MAML2 fusion。 (C) Adenoid cystic carcinoma：MYB-NFIB fusion。 (D) Secretory carcinoma：ETV6-NTRK3 fusion。

32. 下列有關唾液腺腫瘤的敘述，何者錯誤？ (A) 唾液腺的 adenoid cystic carcinoma 雖生長緩慢，但復發率高且易遠端轉 移，預後不佳。 (B) Salivary duct carcinoma 與 high-grade mammary ductal carcinoma 型態相 似，且免疫染色 estrogen receptor (ER)也多為陽性。 (C) 唾液腺原發的 squamous cell carcinoma 很罕見，需先排除是其他部位轉 移而來的可能性。 (D) 除了 periparotid lymph nodes 外，Warthin tumor 幾乎只長在 parotid gland

33. Which of the following are most suitable for juvenile polyps a type of? (A) Adenomatous polyp (B) Hamartomatous polyp (C) Neoplastic polyp (D) Young age of onset

34. Which H. pylori protein is associated with a role in the development of gastric neoplasia? (A) CagA (B) PAR1 (C) SHP2 (D) SRC

36. Which of the following is true about mucinous adenocarcinoma of the colorectum? (A) It is the most common subtype of colorectal carcinoma (B) It unequivocally has a better prognosis than standard colorectal carcinoma (C) It usually affects pediatric patients (D) Signet ring cells are always at least a minor component

37. Sporadic MMR deficient colorectal carcinoma is due to promoter hypermethylation of which of the following genes? (A) MLH1 (B) MSH2 (C) MSH6 (D) PMS2

38. A 60 year old man presents with abdominal pain and a CT reveals a mass within the gastrointestinal system, which is resected. Histopathologic examination reveals a submucosal mass composed of spindle cells with lightly eosinophilic cytoplasm arranged in a syncytial pattern. The pathologic diagnosis is a GIST, spindle cell type. Which of the following answer choices correlates with the most favorable prognosis for this patient? (A) KIT mutation present (B) Mass 11 cm in greatest dimension (C) Mass located in the jejunum (D) Mitotic rate ＞10 per 50HPF

39. A biopsy diagnosis of low grade dysplasia was made by a pathologist and confirmed by a subspecialized GI pathologist. What is the preferred appropriate management based on the ACG 2016 guidelines? (A) Endoscopic ablation therapy (B) Endoscopic mucosal resection (C) Endoscopic surveillance at 6 months interval (D) Endoscopic surveillance at 12 months interval

40. Which of the following statements is true about gastric inflammatory fibroid polyp? (A) Associated with activating mutation in the PDGFRA (B) Benign and nonneoplastic (C) Synonymous with inflammatory polyp (D) Typically centered in the muscularis propria

41. Which of the following descriptions of primary biliary cholangitis (PBC) is wrong? (A) Usually a disease of middle-aged women (B) Interlobular bile duct destruction is the typical feature found in the liver biopsy (C) Most patients are positive for anti-mitochondrial antibody (D) Usually present with jaundice in the beginning