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110年 - 110年度解剖病理專科醫師甄試筆試51-124#108993

科目：解剖病理專科醫師 | 年份：110年 | 選擇題數：74 | 申論題數：0

試卷資訊

所屬科目：解剖病理專科醫師

選擇題 (74)

51. In WHO2016 classification, the urothelial proliferation of uncertain malignant potential refers to the lesion formerly called(A) Papillary urothelial neoplasm of low malignant potential (B)Reactive atypia(C)Dysplasia (D)Papillary and flat urothelial hyperplasia
52. The most compatible immunoprofile of so-called invasive urothelial carcinoma of “luminal type” is(A) CK5/6+ GATA3+ (B)CK5/6- GATA3+(C)CK5/6+ GATA3-(D)CK5/6- GATA3-
53 The triple immunostain cocktail recommended for diagnosing limited prostatic adenocarcinoma (2016 WHO, p.147) comprises (A) AMACR/NKX3.1/high-molecular weight cytokeratin (B)AMACR/p63/ high-molecular weight cytokeratin (C)AE1/AE3/AMACR(D)ERG/PSMA/NKX3.1
54. According to 2016 WHO classification, a dermoid cyst in the testis found in a 20- year-old man is classified as (A)Teratoma, prepubertal-type (B)Teratoma, postpubertal-type (C)Germ cell tumor, type III (D)Non-germ cell tumor
55. Which of the following statements about IgA nephropathy (IgAN) is INCORRECT?(A) Dominant or codominant IgA mesangial staining is essential for diagnosis. (B)Antigenic galactose-deficient IgA1 plays a central role in the pathogenesis of IgAN. IgG or IgA autoantibodies form immune complexes with aberrantly galactosylated IgA1 leading to glomerular deposition.(C)The parameters in Oxford classification of IgAN include mesangial hypercellularity (M), endocapillary hypercellularity( E ), segmental sclerosis (S), interstitial fibrosis/tubular atrophy (T) and crescents ( C ). (D)Henoch-Schönlein purpura also has glomerular mesangial IgA deposition, and can be distinguished from IgAN by renal biopsy.
56. Which of the following statements about membranous nephropathy (MN) is INCORRECT?(A)Primary MN (previously called idiopathic MN) is now considered a kidneyspecific, autoimmune glomerular disease due to autoantibodies against certain native podocyte antigens.(B)The phospholipase A2 receptor (PLA2R) is the antigen in about 70% of patients with primary MN. (C)The presence of endothelial tubuloreticular inclusions by electron microscopy would suggest a diagnosis of primary MN. (D)Thrombospondin type 1 domain-containing 7A (THSD7A), another target antigen of primary MN, may be overexpressed by certain malignancies leading to MN.
57. 下列何者正確? (A) The most frequent cause of dysfunctional uterine bleeding is generalized metabolic disturbances.(B)Activation of the PTEN is a common genetic alteration in both endometrial hyperplasia and endometrioid endometrial carcinoma.(C)High-grade endometrial stromal sarcoma usually has a translocation of JAZF1 gene, fused to a second gene, such as SUZ12. (D)Most vulvar cancers are not related to HPV and develop in a background of lichen sclerosus or squamous cell hyperplasia.
58. 根據 staging of cervical carcinoma to the FIGO 2018 staging system, 下列何者正確? (A) The involvement of vascular/lymphatic spaces and presence of isolated tumor cells do change the stage. (B)Stage III excludes lymph node metastases (identified by image or pathology). (C)Assessment of stage IA disease on the basis of depth of stromal invasion only. (D)Subdivision of stage IB into two size categories.
59. 根據 WHO classification (5th edition) of tumors of the uterine cervix, 下列何者錯 誤?(A) Serous carcinoma of the cervix has been removed because there is no evidence that it occurs as a primary tumor. (B)Adenofibroma has been omitted because it is a rare and controversial entity. (C)The p16 immunostaining or HPV testing is required to distinguish HPV-associated and HPV-independent squamous cell carcinomas. (D)Silva pattern of invasion is applicable to all invasive cervical carcinomas.
60. 以下關於子宮內膜癌的描述，何者為非？ (A) Low-grade endometrial endometrioid carcinoma shows diffuse strong immunoreactivity for estrogen receptor/progesterone receptor and patchy positive for p16. (B)High-copy number alterations and TP53 mutations endometrial carcinomas are associated with intermediate prognosis. (C)POLE mutations are associated with good prognosis. (D)The morphology of most metastases (~90%) from carcinosarcoma contains the carcinomatous component.
61. 以下關於 microsatellite instability-high (MSI-H) 子宮內膜癌的描述，何者為非？ (A) Mutations in or epigenetic silencing of mismatch repair genes leading to genomic instability and high burden of somatic mutations. (B)Associated with mutations that upregulate signaling through the PI3K/AKT pathway. (C)Prevalent in endometrial carcinomas arising in women with hereditary nonpolyposis colorectal carcinoma syndrome (also referred to as Lynch syndrome).(D)In sporadic endometrioid carcinoma, loss of DNA mismatch repair gene is commonly caused by epigenetic silencing.
62. 下列何者錯誤?(A) The most common molecular alteration of ovarian mucinous carcinomas is ERBB2 (HER2) amplifications. (B)Adult granulosa cell tumors contain somatic FOXL2 mutations in more than 90% of cases. (C)A significant proportion of moderately and poorly differentiated Sertoli-Leydig cell tumors contain DICER1 mutations.(D)Deleterious germline or somatic mutations of SMARCA4 implicated the pathogenesis of small cell carcinoma of the ovary of hypercalcemic type.
63. 以下關於 ovarian high-grade serous carcinoma 的描述，何者為非？(A) Either a defective homologous recombination DNA repair pathway or amplification of CCNE1. (B)Some high-grade serous carcinomas arise from serous tubal intraepithelial carcinoma (STIC). (C) BRCA1 and BRCA2 mutations are common in sporadic high-grade serous carcinoma.(D)The biological behavior depends on the extent and distribution of peritoneal disease and lymph node metastasis.
64. 下列何者錯誤? (A) The most common sites of endometriosis are ovaries, uterine ligaments, rectovaginal septum, cul de sac and pelvic peritoneum. (B)Peritoneal and ovarian endometriosis may be a precursor to endometrioid and clear cell carcinomas.(C)Mutations in KRAS, PIK3CA, PPP2R1A and ARID1A have been identified in the epithelial cells of endometriosis of distant sites. (D)The proposed pathogenesis of endometriosis including regurgitation, benign metastasis, metaplastic and extrauterine stem/progenitor cell theories.
65. 乳癌中的 tubular carcinoma 經常是 ER positive、PR positive、HER2 negative、MIB1 labeling index low (usual ＜10%)，請問 tubular carcinoma 是屬於 intrinsic type 中的哪一型？(A) Luminal A type (B)luminal B type(C)HER2 type(D)Basal type type
66. 根據現行 WHO 的診斷標準，用 size criteria 來區分 atypical ductal hyperplasia (ADH) 和 low grade ductal carcinoma in situ(DCIS)的標準，是用多少 mm？ (A) 1mm(B)2mm (C)3mm(D)4mm
67. Breast invasive carcinoma with medullary features 除了常見 tumor infiltrating lymphocyte (TIL)外，還常會有何種基因異常？ (A)KRAS (B)BRAF (C)HER2 (D)BRCA1/2
68. Breast secretory carcinoma 是一種罕見但有特殊基因變異的腫瘤。此特殊變異 不但可以做為診斷上使用，目前也是標靶藥物針對的目標,請問這特殊的基因變異 是甚麼？可做為診斷的重要依據甚至於治療的標的? (A)EGFR L858R (B)BRAF V600E (C)ETV6-NTRK3 (D)EWSR1-ATF1
69. Breast intraductal papilloma with atypical ductal cells proliferation 如何區分 papilloma with ADH 和 papilloma with low grade DCIS 有時是困難的。 但根據現 行 WHO 的診斷標準，用 size criteria 來區分 papilloma with ADH 和 papilloma with low grade DCIS 的標準，是用多少 mm 大小的 atypical ductal focus 來區分？ (A)1mm (B)2mm (C)3mm (D)4mm
70. 病人有乳癌淋巴結轉移，被轉移的一個淋巴結中分別有三個轉移癌，其大小 分別是 0.3mm、0.5mm 及 2.5 mm，依照 AJCC 第八版乳癌病理分期，此病人 pN 為何？ (A)pN0, 標示有 isolated tumor cells (B)pN1micro (C)pN1 (D)pN2
71. HER2 的評估對於是否用 anti-HER2 的標靶藥物選用上至關重要，在 HER2 immunohistochemical stain 為 2+/ equivocal 時，是需要作 HER2 FISH/DISH 來確 認是否有 HER2 amplification。請問根據最新 ASCO/CAP guideline HER2 signal/CEP 17 signal 的比值(Ratio)要為多少時，才算 HER2 amplification？ (A)＞=2.0 (B)＞=2.2 (C)＞=4.0 (D)＞=6.0
72. Triple negative breast carcinoma(TNBC)包含一群異質性乳癌，並非全部都是預後很差。請問下列何者的預後是屬於比較好的 TNBC？ (A)Pleomorphic ILC (B)High grade spindle cell carcinoma (C) Tubular carcinoma (D)Low grade adenosquamous carcinoma
73. 關於甲狀腺毒症(thyrotoxicosis)之成因，下列何者最不可能(A)葛瑞夫茲氏病(Graves disease) (B)濾泡癌(follicular carcinoma) (C)橋本氏甲狀腺炎(Hashimoto thyroiditis) (D)結節性甲狀腺腫(multinodular goiter)
74. 關於橋本氏甲狀腺炎(Hashimoto thyroiditis)之描述，下列何者為非(A)發病前數天常有上呼吸道病毒感染之病史 (B)好發於女性 (C)屬於自體免疫之發炎性疾病 (D)常造成甲狀腺功能低下
75. 關於甲狀腺乳突癌(papillary carcinoma)之描述，下列何者為非(A)最常見之甲狀腺惡性腺腫瘤 (B)放射線接觸是其致病之危險因子 (C)其最常見之基因變異為 RAS 基因突變 (D)十年疾病存活率大於 95%
76. 關於診斷甲狀腺濾泡腫瘤，下列何者為非 (A)處理檢體時，應完整包埋腫瘤包膜與周圍甲狀腺組織之交界 (B)腫瘤包膜侵犯(capsular invasion)與血管侵犯(vascular invasion)為診斷濾泡癌 (follicular carcinoma)之病理學特徵 (C)濾泡瘤(follicular adenoma)與濾泡癌在病理檢查皆可發現微濾泡(microfollicle) 增生 (D)甲狀腺細針抽吸細胞學可直接診斷濾泡癌
77. 下列何者不是副甲狀腺機能亢進之臨床症狀(A)囊狀纖維性骨炎(osteitis fibrosa cystica) (B)腎鈣化症(nephrocalcinosis) (C)高血壓(hypertension) (D)憂鬱(depression)
78. 下列何者不是庫興氏症候群(Cushing syndrome)之成因 (A)腦下腺瘤 (B)腎上腺瘤 (C)肺癌所產生之腫瘤附屬症候群(paraneoplastic syndrome) (D)口服睪固酮
79. 下列何者不是第二型多發性內分泌瘤症候群(MEN type 2)之臨床表現(A)腦下腺瘤(pituitary adenoma) (B)副甲狀腺增生(parathyroid hyperplasia) (C)甲狀腺髓質癌(medullary thyroid carcinoma) (D)嗜鉻細胞瘤(pheochromocytoma)
80. 下列何種眼角膜病變，其典型之病理學特徵為 guttate excrescences (A)Fuchs dystrophy (B)Bullous keratopathy (C)Keratoconus (D)Granular dystrophy
81. Bullous pemphigoid 是一種自體免疫水泡病，下列何者是 bullous pemphigoid 的 病理特徵? (A)Suprabasal blisters or bullae (B)Autoantigens 位在基底膜(basement membrane)的 lamina lucida。 (C)使用 direct immunofluorescence 檢查，可區別 epidermolysis bullosa acquista。 (D)嗜中性白血球(neutrophil) 浸潤是重要病理診斷依據。
82. 下列何種皮膚發炎性疾病較少出現 interface dermatitis? (A)Discoid lupus erythematosus (B)Erythema multiforme (C)Morphea (D)Dermatomyositis
83. Merkel cell carcinoma 的特徵何者為非? (A)CK20 免疫染色可用來區別轉移性肺小細胞癌(metastatic small cell carcinoma of lung) (B)Merkel cell carcinoma 的發生與 polyoma virus 有關 (C)Merkel cell carcinoma 的發生與 UV radiation 無關 (D)多發生生成年與老年人
84. Basal cell carcinoma 有許多 morphologic variants，請問何者有較高的復發風險 (high risk of recurrence) ? (A)Basosquamous carcinoma (B)Fibroepithelioma of Pinkus (C)Nodular basal cell carcinoma (D)Infundibulocystic basal cell carcinoma
85. 黏液堆積(mucin deposition) 在真皮，較少出現在下列何種發炎性皮膚病? (A)Lupus erythematosus (B)Granuloma annulare (C)Dermatomyositis (D)Pityriasis lichenoides
86. 有關 malignant melanoma 的描述何者錯誤? ((A)與 acral melanoma 相比較，BRAF V600E 突變更常出現於 superficial spreading melanoma。 (B)使用 immune checkpoint inhibitor-pembrolizumab 治療 melanoma，要先做 PD-L1 IHC 22C3 pharmDx 免疫組織化學染色，Tumor Proportion Score (TPS)＞=50%，即符合適應症。 (C)Lentigo maligna melanoma 是屬於 high cumulative sun damage (high CSD)的 melanoma。 (D)Ulceration 是 poor prognostic factor。
87. 一個大腸腺癌病人的軀幹有多個皮脂腺腫瘤(sebaceous tumor)，病人有癌症家 族史，針對皮脂腺腫瘤，你會優先考慮進行下列何種免疫組織化學染色以發現癌 症家族史的可能原因? (A)p53 (B)BRAF V600E (C)BAP-1 (D)Mismatch repair protein
88. 何者不是 psoriasis vulgaris 的特徵? (A)致病機轉與 TH2 cells (T help type 2 cells)有關 (B)Dilated and tortuous capillaries in dermal papillae (C)可用 tumor necrotic factor inhibitor 治療 (C)有些病人會出現關節炎
89. 下列 adipocytic neoplasms，何者比較不會出現 mature hyaline cartilage？ (A)Lipoma (B)Chondroid lipoma (C)Myxoid liposarcoma (D)Dedifferentiated liposarcoma
90. 下列 primary bone tumors，何者非僅由腫瘤類型決定 grade？ (A)Clear cell chondrosarcoma (B)Periosteal osteosarcoma (C)Leiomyosarcoma (D)Ewing sarcoma
91. 下列幾類腫瘤，何者被公認應歸類為 nerve sheath tumor 而較無爭議？
 (1) Granular cell tumor
 (2) Ectomesenchymoma 
(3) Malignant triton tumor
 (4) Biphenotypic sinonasal sarcoma
 (5) Lipofibromatosis-like neural tumor (A)(1)(2)(3)(5) (B)(2)(4)(5) (C)(1)(3)(5) (D)(1)(3)
92. 下列腫瘤的配對，有相似的型態病理學特徵，近年更因發現有共同的基因變 異而加強兩者之間的連結，何組配對例外？ (A)Osteoid osteoma & osteoblastoma (B)Myositis ossificans & aneurysmal bone cyst (C)Giant cell tumor of bone & giant cell tumor of soft tissue (D)Non-ossifying fibroma & central giant cell granuloma of the jaw bones
93. 下列骨骼疾病之 pathogenesis，何者與直接或間接之 osteoclast 過度活化較無 關？ (A)Paget disease (B)Osteopetrosis (C)Brown tumor (D)Giant cell tumor
94. 下列鑑別診斷方式（若只考慮各選項中之兩個診斷時），何者較正確？ (A)Epithelioid sarcoma vs. pseudomyogenic hemangioendothelioma: CD31 陰性即為前 者，ERG 陽性即為後者 (B)Synovial sarcoma vs. malignant peripheral nerve sheath tumor: TLE1 陽性即為前 者，S100 protein 陽性即為後者 (C)Dedifferentiated liposarcoma vs. dedifferentiated solitary fibrous tumor: STAT6 之 核染色，陰性即為前者，陽性即為後者 (D)Chondroblastoma vs. phosphaturic mesenchymal tumor: Histone H3.3 K36M 染色 陽性即為前者，FGF23 RNA CISH 強陽性即為後者
95. 青少年的軟組織腫瘤，切片呈現 round cell neoplasm 樣貌，免疫染色呈現 Desmin (+, diffuse)，EMA (+, focal)，CD99 (+, focal)，WT1 (-, epitope 不明)， CD45 (-)，且已知有某種 EWSR1 driver fusion gene。下列何種診斷比較不可能？ (A)Alveolar rhabdomyosarcoma (B)Angiomatoid fibrous histiocytoma (C)Desmoplastic small round cell tumor (D)Round cell sarcoma with EWSR1-PATZ1 fusion

96. 一位 65 歲女性，無腫瘤病史，發現全身多處腫塊，whole body PET (下圖) 及 MRI 顯示軟組織、骨、腦、肺有多個 1-2 cm 之腫瘤，PET 另外發現左心房內有 約 4.5 cm 區域之高代謝性疑似病灶。頸部、上顎、脊椎三處腫瘤之組織切片，病 理檢驗皆顯示為 spindle cell neoplasm with moderate pleomorphism and increased mitoses，分化方向不明確，FISH 則發現 MDM2 amplification。

 

關於這些腫瘤，下列描述何者最可能是正確的？ (A)依部位相關發生率來說，此腫瘤最有可能是 angiosarcoma (B)FNCLCC grade 是已知的最重要預後因子 (C)常見的 copy number 異常包括 PDGFRA & EGFR gain 及 CDKN2A loss (D)TP53 missense mutation 是最常見的基因變異

97.下列關於腦下垂體疾病的敘述，何者錯誤? (A)現今常用於分類 pituitary adenoma 的 cell type–specific Transcription factors， 包括 PIT-1，TPIT，steroidogenic factor-1 (SF-1) 等 (B)Pituitary blastoma 常發生在小於 2 歲的小孩而且伴隨有 DICER1 germ line mutation (C)Pituitary apoplexy 是腦下垂體疾病突然出血所造成的變化，病人通常會有突然 惡化的臨床表現如劇烈頭痛，複視等臨床表現，一般而言需要緊急手術的介入 治療 (D)造成 hypopituitarism 合併有 diabetes insipidus 的情形，最常見的原因是腦下垂 體本身的疾病所引起

98. 16 歲女孩被父母帶來急診，症狀為這兩週開始漸進性頭暈、目眩、合併病態 不穩，最近一個月經常性原因不明嘔吐，體重減輕兩公斤。病患檢查爲意識清 楚，無發燒，有營養不良與言語不清，複視(diplopia)、旋轉性眼球震顫 (rotatory nystagmus) 、及四肢輕癱 (quadriparesis)。病患非素食主義者也無酗 酒。住院治療期間因心因性休克而過世，病理解剖之腦部如下圖：

 

以下何者爲最可能的診斷? (A)Mitochondrial Encephalomyopathy (B)Wernicke encephalopathy (C)Multiple sclerosis (D)Cobalamin deficiency related neurological disea

99.下列關於周邊神經病變 (peripheral neuropathy)的敘述，何者為錯？ (A)感染水痘(chickenpox)後 varicella-zoster virus (VZV) 會潛伏在感覺神經節中， 當宿主免疫力低下時病毒會伺機再活化，病毒會沿著神經所支配神經皮節引起 劇烈疼痛之皮膚水泡俗稱皮蛇(shingles)。 (B)Guillain-Barré syndrome 為一種不常見的疾病，目前認為是細菌性 (Campylobacter jejuni)、病毒性 (cytomegalovirus)或黴漿菌感染後誘發 myelinreactive B cells 或其它分子相似物 (molecular mimicry)而導致疾病的產生。 (C)周邊神經病變最常見的原因是糖尿病。 (D)Cisplatin、vinca alkaloids、taxanes 等化療藥物是造成周邊神經病變最負盛名的 藥物。
100. 80 歲婦女被送到急診室，因為她在浴室往後跌倒並撞到頭，急診檢查發現 後腦勺有一 3 公分紅腫頭皮外傷，病人意識不佳但可以喚醒，影像學檢查發 現腦部有急性出血，請問此病患腦出血最可能的部位是在下列何處？ (A)Basal ganglia (B)Cerebral ventricle (C)Inferior frontal lobe (D)Pineal region
101. Epithelioid glioblastoma 分子病理變化，下列何者最爲可能? (A)BRAF V600E mutation (B)FGFR alteration (C)IDH-1 mutation (D)MYB-QK1 rearrangement
102. Papillary craniopharyngiomas 的突變基因，下列何者最爲可能？ (A)beta-catenin (B)BRAF V600E (C)p53 (D)SMARCB1
103. 22 歲女性因為兩側聽力不良求診，影像檢查兩側小腦橋部(CP angle)腫瘤， 術後病理診斷為 Schwannoma，下列何者最有可能與此病患具有關聯性？ (A)Hamartin (B)Merlin (C)Neurofibromin (D)Tuberin
104. 關於視神經脊髓炎 (Neuromyelitis Optica)，下列何者最有可能與此病有關聯 性？ (A)ApoE (B)Aquaporin-4 (C)SOD1 (D)TDP-43

105. A 5-year-old girl, fine needle aspiration for LN: What is the most likely diagnosis?

(A) Birkitt lymphoma (B)Small cell carcinoma (C)Infectious mononucleosis (D)Large cell lymphoma (E)None of the above

106. A 55-year-old woman with hematuria, urine cytology: What is the most likely diagnosis?

(A) CMV inclusion (B)Malakoplakia (C)Urothelial carcinoma, low grade (D)Adenocarcinoma

107. What is the correct diagnosis of this Pap smear obtained from a 55-year-old woman with post-menopausal vaginal bleeding?

(A) Endometritis (B)Repair cells (C)Endocervical adenocarcinoma (D)Endometrial adenocarcinoma (E)Extra-uterine adenocarcinoma

108. What is the most possible diagnosis of this Pap smear obtained from a 35-year-old woman with routine check?

(A) High grade intraepithelial lesion (B)Reactive endocervical glandular cells (C)Adenocarcinoma in situ (D)Adenocarcinoma
109. 一個好的 laboratory，其 ASCUS 的比例最好應低於 SIL 的 (A) 3 倍 (B)4 倍 (C)5 倍 (D)6 倍

110. The cells shown here are noted in the Pap smear of a 65-year-old woman with postmenopausal bleeding. The most possible diagnosis ?
(A) Adenocarcinoma (B)Squamous cell carcinoma (C)Malignant mixed mullerian tumor (D)以上皆非

111. 子宮頸抹片中有以下發現, 與下列何者最為相關?
(A) HPV infection (B)Trichomonas infection (C)Intrauterine device (IUD) (D)Pregnancy (E)Diabetes

112. 子宮頸抹片, 36 歲, 例行年度篩檢, 圖中所指細胞最合適選項為何?

(A) Benign endometrial cells (B)Parabasal squamous cells in atrophy (C)Endometrial adenocarcinoma (D)High-grade squamous intraepithelial lesion (HSIL) (E)Endocervical adenocarcinoma
113. Large and prominent nucleoli may be found in the following conditions, EXCEPT: (A) Status post radiotherapy (B)In decidual cells (C)In repair cells (D)In high grade intraepithelial lesion (HSIL) cells (E)In Adenocarcinoma
114. Intranuclear inclusion or nuclear pseudo-inclusion may occur in all the followings EXCEPT…. (A) Malignant melanoma (B)Hepatocellular carcinoma (C)Meningioma (D)Squamous cell carcinoma (E)Papillary thyroid carcinoma

115. 甲狀腺抽吸, 如圖所示, 最合理診斷為?
(A) Medullary carcinoma (B)Follicular carcinoma (C)Papillary carcinoma (D)Anaplastic carcinoma (E)Nodular goiter

116. 56 歲女性,staging surgery for endometrial cancer, peritoneal washing cytology 有此發現, 圖中所指細胞最合適選項為何?
(A) Endometrial adenocarcinoma (B)Reactive mesothelial cells (C)Cauterized tubal epithelium (D)Colon adenocarcinoma
117. Fine needle aspiration (FN(A) of breast is most reliable in which of the following differential diagnoses? A) To distinguish ductal proliferative lesions, including usual ductal hyperplasia, atypical ductal hyperplasia and low-grade ductal carcinoma in situ (B)To distinguish high-grade ductal carcinoma in situ form invasive carcinoma (C)To distinguish intraductal papilloma from florid ductal hyperplasia (D)To distinguish fibroadenoma from phyllodes tumor (E)To distinguish fibroadenoma from invasive carcinoma

118. The smear was prepared from the FNA of a thyroid nodule in a 44-year-old woman. According to the thyroid TBS, what is the best diagnosis?

(A) Benign follicular nodule (B)Atypia of undetermined significance (C)Suspicious for follicular neoplasm (D)Suspicious for Papillary carcinoma (E)Suspicious for parathyroid neoplasm
119. 劉氏染色法與柏氏染色法之比較，何者為錯誤： (A) 柏氏染色法之胞核細部清楚 (B)劉氏染色法適合血液學病變 (C)劉氏染色法具有異染色性 (metachromasia) (D)Virus 之細胞學變化以劉氏染色法染色較佳 (E)黴菌之細胞學變化以劉氏染色法染色較佳

120. 子宮頸抹片, 36 歲, 例行年度篩檢, 有關圖中所示細胞, 最合適選項為何?
(A) Indicating progesterone effect (B)Low grade intraepithelial lesion (C)Changes compatible with intra-uterine device (D)Decidual cells
121.如果評估尿液檢體中之 Papillary clusters of cells, 下列資訊哪一個是最重要的? (A) Knowledge of specimen color/texture (B)Knowledge of specimen collection method (C)Knowledge of history of urinary tract infection (D)Knowledge of history of urothelial carcinoma (E)Knowledge of history of prostate cancer

122. 腹水細胞學檢查有以下發現, 請問最有可能之病灶在?
(A) Stomach (B)Gall bladder (C)Appendix (D)Pancreas
123. 有關尿液細胞學, 下列何者是正確的? (A) Urine cytology is reliable in distinguishing reactive urothelial cells from low-grade urothelial carcinoma (B)Urine cytology is reliable in distinguishing papillary lesions from flat lesions (C)Urine cytology is reliable in distinguishing in situ from invasive urothelial carcinoma (D)Urine cytology is reliable in diagnosing high-grade urothelial carcinoma (E)Urine cytology is reliable in diagnosing renal cell carcinoma

124. Pleural effusion, 36 歲, 女性, 有關圖中細胞發現, 應該建議優先做什麼檢查?
(A) CT of lung to rule out lung cancer (B)Acid fast stain to rule out tuberculosis (C)Flow cytometry to rule out lymphoma (D)Autoantibodies to rule out SLE

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