37. 有關於 phosphodiesterase4(PDE4)inhibitors 的藥物用於 COPD 治療，下列何者為非 : (A) By its mechanism, PDE4 inhibitors decrease airway inflammation and have direct bronchodilator activity. (B) PDE4 inhibitors has been approved for patients with severe to very severe COPD patients and frequent exacerbations. (C) Guidelines recommend that PDE4 inhibitors be used in combination with a long acting bronchodilators (D) Monitoring weight during treatment is warranted.