38. A 60 year old man presents with abdominal pain and a CT reveals a mass within the gastrointestinal system, which is resected. Histopathologic examination reveals a submucosal mass composed of spindle cells with lightly eosinophilic cytoplasm arranged in a syncytial pattern. The pathologic diagnosis is a GIST, spindle cell type. Which of the following answer choices correlates with the most favorable prognosis for this patient?
(A) KIT mutation present
(B) Mass 11 cm in greatest dimension
(C) Mass located in the jejunum
(D) Mitotic rate ＞10 per 50HPF

34. Which H. pylori protein is associated with a role in the development of gastric neoplasia? (A) CagA (B) PAR1 (C) SHP2 (D) SRC

35. Which of the following is true about medullary carcinoma of the colon? (A) It accounts for 20% of colorectal carcinomas (B) It is poorly differentiated, with a poor prognosis (C) It most often arises in elderly women (D) It usually arises in the rectosigmoid

36. Which of the following is true about mucinous adenocarcinoma of the colorectum? (A) It is the most common subtype of colorectal carcinoma (B) It unequivocally has a better prognosis than standard colorectal carcinoma (C) It usually affects pediatric patients (D) Signet ring cells are always at least a minor component

37. Sporadic MMR deficient colorectal carcinoma is due to promoter hypermethylation of which of the following genes? (A) MLH1 (B) MSH2 (C) MSH6 (D) PMS2

39. A biopsy diagnosis of low grade dysplasia was made by a pathologist and confirmed by a subspecialized GI pathologist. What is the preferred appropriate management based on the ACG 2016 guidelines? (A) Endoscopic ablation therapy (B) Endoscopic mucosal resection (C) Endoscopic surveillance at 6 months interval (D) Endoscopic surveillance at 12 months interval

40. Which of the following statements is true about gastric inflammatory fibroid polyp? (A) Associated with activating mutation in the PDGFRA (B) Benign and nonneoplastic (C) Synonymous with inflammatory polyp (D) Typically centered in the muscularis propria

41. Which of the following descriptions of primary biliary cholangitis (PBC) is wrong? (A) Usually a disease of middle-aged women (B) Interlobular bile duct destruction is the typical feature found in the liver biopsy (C) Most patients are positive for anti-mitochondrial antibody (D) Usually present with jaundice in the beginning

42. The natural history of chronic HBV infection is divided into 3 phases: immune tolerance phase, immune clearance phase and viral integration phase. Which of the following description of viral integration phase is correct? (A) The serum HBV DNA level is still high (B) The liver inflammation is usually mild or already cirrhotic (C) HBsAg becomes negative (D) HBcAg is usually positive

43. Which of the following description about exocrine pancreatic carcinoma is Wrong (A) The spindle tumor cells of undifferentiated carcinoma of pancreas are positive for cytokeratin, but always negative for vimentin (B) the average size of tumors at the pancreatic head region is usually smaller than tail region (C) Acinar cell carcinoma of pancreas has better survival in pediatric patients than adult patients (D) The osteoclast-like giant cells in the undifferentiated carcinoma with osteoclast like giant cells (UC-OGC) of pancreas is considered as benign in nature

44. Which of the following description about Wilson’s disease is Correct? (A) Decreased urinary excretion of copper (B) Kayser-Fleischer rings can be seen in the eye with a brown color (C) For children, it usually presented as liver disease. (D) The serum ceruloplasmin is increased