46.梅毒（syphilis）有效的治療，其VDRL血清檢測（1：32）在12～24個月間，其濃度至少應下降達 下列何種程度？
(A)1倍
(B)2倍
(C)4倍
(D)8倍

答案：登入後查看
統計： A(1), B(21), C(399), D(78), E(0) #3378387

詳解 (共 2 筆)

#6428941

  • 梅毒（Syphilis）治療後的血清學監測通常透過非特異性試驗如 VDRL 或 RPR。

  • 治療有效的標誌是血清試驗的滴度（titer）明顯下降。

具體標準：

  • 一般認為治療後 12～24個月內，VDRL 滴度應至少下降 4倍（即下降兩個稀釋階段，例如從1:32降到1:8）。

  • 若無明顯下降，可能表示治療失敗或感染復發。

小補充：

  • 4倍下降 是國際標準指標，用以判斷治療反應良好。

5
0
#6292586
Treponema pallidum cannot be cultured from clinical speci-mens. Definitive diagnosis of early-stage lesions is made using dark-field examination and direct immunofluorescent antibody staining of lesion exudates (Centers for Disease Control and Prevention, 2010b). In asymptomatic patients or for screening purposes, serological testing is used. There are two types. The first type is nontreponemal testing that includes the Venereal Disease Research Laboratory (VDRL) and the rapid plasma
reagin (RPR). These tests are quantified and expressed as titers. Because titers reflect disease activity, they increase during early syphilis and often exceed levels of 1:32 in secondary syphilis. Following treatment of primary and secondary syphilis, sero-logical testing at 3 to 6 months usually confirms a fourfold drop in VDRL or RPR titers (Rac, 2014a). Those with treatment failure or reinfection may lack this decline. Because VDRL titers do not correspond directly to RPR titers, consistent use of the same test for surveillance is recommended.
2
0