49. Which of the following is not true concerning silent mutations? (A) Silent mutations refer to base sequence differences that do not change the amino acid coded for. (B) Only changes in base sequence that lead to a different amino acid can have an effect on the organism. (C) Changes in the sequence of an exonic splicing enhancers can lead faulty removal of introns. (D) Silent mutations in a gene for pain tolerance have been correlated with human differences in perception of pain. (E) Translation kinetics and protein folding can be affected by silent mutations.