56.藥品引起neutropenia後，有關恢復時間長短之比較，下列選項何者正確？①cyclophosphamide ②palbociclib ③carmustine
(A)①＞②＞③
(B)③＞①＞②
(C)②＞①＞③
(D)①＞③＞②

carmustine: Nitrosoureas 延遲性骨髓抑制，需要 4~6 週血球才能恢復

cyclophosphamide: Peripheral blood cell counts are expected to normalize after approximately 20 days.

palbociclib: In the PALOMA-2 and PALOMA-3 trials, neutropenia was the most common adverse effect reported in patients receiving palbociclib (80% and 83%, respectively), with grade > 3 neutropenia accounting for the majority of cases (66% in both trials). The median time to onset of neutropenia was 15 days with an average duration of 7 days.

想請教，carmustine是在給藥4~6週後會有延遲性Myelosuppression，其leukopenia發生在5~6週後，但持續時間是1~2週，這樣不是代表恢復時間只有1~2週嗎?

-UpToDate

其餘兩個如同2樓所說

Cyclophosphamide

-UpToDate

Palbociclib

-UpToDate

但這樣看起來cyclophosphamide會變最久耶?