61.有關colchicine的敘述，下列何者正確？
(A)與acidifying agent併用會加強colchicine之作用
(B)與atorvastatin併用會增加橫紋肌溶解症之發生率
(C)與fluconazole併用可能會降低colchicine的血中濃度
(D)僅適用於痛風急性發作治療

1.Alkalinizing agents:The action of colchicine is potentiated by alkalinizing agents. Avoid coadministration. 

2.Grapefruit juice ：Colchicine plasma concentrations may be elevated by grapefruit juice ingestion, increasing the risk of toxicity (eg, myopathy). Advise patients taking colchicine not to consume grapefruit juice. 

3.Moderate CYP3A4 inhibitors (eg, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil) ：

Colchicine plasma concentrations may be elevated, increasing the risk of toxicity (eg, myopathy). Coadminister with caution, starting at reduced colchicine doses, and increase monitoring of creatine phosphokinase and for adverse reactions. If colchicine toxicity is suspected, discontinue colchicine.

4.Cyclosporine, digoxin, fibric acids (eg, fenofibrate, gemfibrozil), HMG-CoA reductase inhibitors (eg, atorvastatin, fluvastatin, pravastatin, simvastatin) ：

The risk of myopathy or rhabdomyolysis may be increased. If coadministration cannot be avoided, monitor the patient for signs of any unexplained muscle pain, tenderness, or weakness. If colchicine toxicity is suspected, discontinue colchicine.