65 下列屬於 Triptans 類之藥品中，何者與 CYP3A4 抑制劑具有最顯著之交互作用，應避免合併使用？
(A) Eletriptan
(B) Rizatriptan
(C) Zolmitriptan
(D) Frovatriptan

答案：登入後查看
統計： A(770), B(499), C(443), D(122), E(0) #411256

詳解 (共 5 筆)

#896228
(A) Eletriptan：3A4 排除
(B) Rizatriptan：MAO-A 排除
(C) Zolmitriptan：MAO-A , 1A2 排除
(D) Frovatriptan：1A2 排除
94
0
#2900832

Sumatriptan 經MAO-A代謝、不經過CYP450

25
0
#4159946
記：Eletriptan 的E像是倒過來...
(共 24 字，隱藏中）
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13
1
#5878119
Triptan類PK/PD考點補充：1....
(共 270 字，隱藏中）
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10
0
#5504699
Inhibitors of cytochrome P-450 (CYP) 3A4 reduce the clearance of almotriptan and eletriptan. For almotriptan, increased exposure to triptans should be anticipated; however, no specific dosing adjustments are proposed. The interaction between eletriptan and CYP 3A4 inhibitors is more significant, and particular precautions are necessary. Eletriptan should not be used within 72 hours of treatment with potent CYP 3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir).
Applied 10e p1345
1
0

私人筆記 (共 2 筆)

私人筆記#2336775
未解鎖
。。。3a4代謝 almotripta...
(共 33 字，隱藏中）
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10
0
私人筆記#7091386
未解鎖
Triptan類用藥補充： 皆為5-H...
(共 280 字，隱藏中）
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2
0