66.下列何者為長效白血球生長刺激素？
(A)filgrastim
(B)lenograstim
(C)sargramostim
(D)pegfilgrastim

PEG相關的生物藥劑概念可以看一下~

1. 接法：共價、非共價連接。

PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.

2. 在藥物動力學中的角色：使藥物不易被免疫系統破壞、增加藥物體積不易被腎臟清除 → 長效

PEGylation is routinely achieved by the incubation of a reactive derivative of PEG with the target molecule. The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reducing immunogenicity and antigenicity), and increase its hydrodynamic size(size in solution), which prolongs its circulatory time by reducing renal clearance.

3. 難容性藥物：增加疏水性藥物的水中溶解度

PEGylation can also provide water solubility to hydrophobic drugs and proteins. Having proven its pharmacological advantages and acceptability, PEGylation technology is the foundation of a growing multibillion-dollar industry. 

（參考維基百科：https://en.wikipedia.org/wiki/PEGylation）