73. 有關於 phosphodiesterase-4 (PDE4) inhibitors 的藥物用於 COPD 治療，下列何者為非： (A) By its mechanism, PDE4 inhibitors decrease airway inflammation and have direct bronchodilator activity. (B) PDE4 inhibitors has been approved for patients with chronic bronchitis and a history of exacerbation (C) Guidelines recommend that PDE4 inhibitors be used in combination with a long-acting bronchodilators (D) Monitoring weight during treatment is warranted.