76.下列何種抗癌藥會抑制細胞有絲分裂？
(A)Chlorambucil
(B)Cyclophosphamide
(C)Melphalan
(D)Estramustine

答案：登入後查看
統計： A(953), B(589), C(753), D(2278), E(0) #624481

詳解 (共 10 筆)

Swear

B2 · 2015/05/27

#1071742

Estramustine（為estrogen之衍生物）會代謝為estromustine，可接上microtubule-associated protein，以穩定microtubules導致細胞無法分裂而達到毒殺癌細胞作用。

Estromustine會再代謝為estrogen及estradiol，故可抑制雄性激素，治攝護腺癌。

194

jane90191

B6 · 2017/06/23

#2289446

只有D跟ABC不同結構分類

ABC是nitrogen mustard

D是nitrosourea

lolo

B7 · 2017/07/13

#2335659

樓上~

根據micromedex

estramustine也是nitrogen mustard耶><

Liliaceae

B4 · 2015/12/25

#1225459

(A)Chlorambucil ...

(共 134 字，隱藏中）

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Ian

B5 · 2016/01/13

#1241194

Although this compound was initially designed as an alkylating agent, it has no alkylating activity. • Inhibits microtubule structure and function and the process of microtubule assembly by binding to microtubule-associated proteins (MAPs).

Swear

B3 · 2015/12/03

#1211350

Estramustine induces an arrest in G2/M phase of the cell cycle due to the inhibit microtubule function.

600

B1 · 2015/01/08

#972351

Its therapeutic actions are believed to be related to its ability to depolymerising the microtubules (which it achieves by binding to microtubule associated proteins), this arrests prostate cancer cells in the G2/M phase of the cell cycle.[4][5][6] It is selectively taken up by prostate cells and hence produces minimal cytotoxic effects on healthy tissue.