79.下列何者兼具DNA嵌入（intercalation）、烷化（alkylation）及使DNA斷裂（cleavage）等抗癌機轉？
(A)Mitomycin
(B)5-FU
(C)Cisplatin
(D)Tretinoin

答案：登入後查看
統計： A(3023), B(452), C(1163), D(105), E(0) #537390

詳解 (共 6 筆)

小羊

B2 · 2015/06/20

#1097737

(A) Mitomycin:

1. Quinone → Free radical。

2. Aziridine → Alkylating。

3. Carbamate(Urethane) → Alkylating。

(B) 5-FU:

需轉換成5-FdUMP抑制thymidylate synthetase使N⁵，N¹⁰-methylene tetrahydrofolic acid (leucovorin) 輔酶無法進行反應。

(C) Cisplatin:

會進入細胞在低氯環境中釋出Cl，接著藥物會結合DNA 中guanine的N7而形成股間與股內的交互連結。

(D) Tretinoin:

又稱trans-retinoic acid，進入細胞核予PML-RAR反應，除去co-repressor吸引co-activator，治療急性前骨髓性白血病(APL)。

174

B3 · 2017/02/06

#1611303

80.下列何者在細胞內經酵素還原成烷化劑後，與DNA反應形成交聯（cross-linked）結合物？
(A)Mitomycin
(B)Methotrexate
(C)Fludarabin
(D)Vinorelbine

專技 - 藥理學與藥物化學- 104 年 - 104-1-藥師(一)-藥理學與藥物化學#19185

答案：A

Bryan

B1 · 2014/05/26

#846412

The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. One of these compounds, mitomycin C, finds use as a chemotherapeutic agent by virtue of its antitumour antibiotic activity. It is given intravenously to treat upper gastro-intestinal, anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage.