複選題

13. Which of the following is/are the occupational exposure agent classified by International Agency for Research on Cancer (IARC) as group 1 definite human carcinogen?
(A) Beryllium
(B) Di(2-ethylhexyl)phthalate
(C) 2-Naphthylamine
(D) Soot
(E) Wood dust

複選題9. Which of the following unit of the radiation activity is/are CORRECT? (A) The units of measurement for radioactivity are the becquerel (Bq, international unit) and the curie (Ci, U.S. unit) (B) The unit used for effective dose is sievert (Sv, international unit) or rem (U.S. unit) (C) A millisievert is one hundred of a sievert (D) The unit for absorbed dose is the gray (Gy, international unit) or the rad (U.S. unit) (E) One gray is defined as 1 joule of energy released in 1 g of tissue

複選題10. Which of the following is/are NOT the protein(s) produced by fat cells under direction of the ob gene that can decrease appetite and increase energy expenditure? (A) Adiponectin (B) Biotin (C) Fatty acid-binding protein (D) Klotho (E) Leptin 

複選題11. Which of the following environment pollutants are endocrine-disrupting chemicals? (A) Bisphenol A (B) Benzo(a)pyrene (C) ẞ-naphthoflavone (D) Polychlorinated biphenyls (E) 2,3,7,8-tetrachlorodibenzo-p-dioxin

複選題12. The compound is/are formed in foods that are high in carbohydrate, but low in protein, which are subjected to processing temperatures of at least 120°C. The presence of ammonium bicarbonate as a leavening agent increases the formation of the compound. Which of the following is/are the compound? (A) Acyclovir (B) Acrylamide (C) Benzo[a]pyrene (D) Furans (E) Polychlorinated biphenyls

複選題14. Which of the following is/are NOT CORRECT about the core components of Metabolic Syndrome? (A) Increased central obesity (B) Insulin resistance (C) Decreased fasting insulin (Type 1 diabetes) (D) Increased blood urea nitrogen and creatinine levels (E) Increased serum triglycerides and hypertension

複選題15. Regarding to the nuclear receptor coactivators which statement(s) is (are) CORRECT? (A) The coactivator might contain the histone acetyl transferase (HAT) domain (B) The coactivator may contain the RNA binding domain (C) The mechanisms and activity could be the tissue-specificity to hormone-responses. (D) The coactivators are unique and specific to a specific nuclear receptor. (E) The co-activator might contribute to the regulation of gene expression.

複選題16. Regarding to the applications of fluorescence labbeled monoclonal antibody which statement(s) is (are) CORRECT? (A) To isolate sub-population of cells via flow cytometry  (B) To identify specific RNA expression via real time Q-PCR (C) To identify specific protein for immunofluorescence (IF) image. (D) To quantify the protein level via Western blotting (E) To identify a specific DNA adduct

17. What are the paired colors to show the colocalization of two fluorescent probes or two pseudo- colors in a specimen? (A) Alexa Fluor 488 and Cy3: orange and yellow (B) eGFR and DsRed: Blue (C) Blue and Red: Magenta (D) Blue and Green: Cyan (E) Green and Red: Yellow

複選題18. Regarding to the high throughput techniques and the "Omics", which pairs are CORRECT? (A) RNA-seq: Transcriptomics (B) Bisulfite sequencing: Epigenetics (C) Image-based high content analysis (HCA): Cytomics (D) LC-MS/MS: Proteomics (E) Q-PCR: Phosphoproteomics

複選題19. Regarding to the statements of the onco-immunology (IO), which are CORRECT? (A) PD1/PDL1 is the immune checkpoint pathway (B) Antibody to stimulate the PD1 has shown the therapeutic benefit for cancer patients (C) Activation or up-regulation of PDL1 in tumor cells could inhibit the T-cell activation (D) Lower level of PDL1 in tumor tissues might show the better outcome of patients with cancer immunotherapy (e.g., Pembrolizumab) (E) The adverse effects of the cancer immunotherapies include interstitial pneumonitis