複選題

16. Regarding to the applications of fluorescence labbeled monoclonal antibody which statement(s) is (are) CORRECT?
(A) To isolate sub-population of cells via flow cytometry 
(B) To identify specific RNA expression via real time Q-PCR
(C) To identify specific protein for immunofluorescence (IF) image.
(D) To quantify the protein level via Western blotting
(E) To identify a specific DNA adduct

複選題12. The compound is/are formed in foods that are high in carbohydrate, but low in protein, which are subjected to processing temperatures of at least 120°C. The presence of ammonium bicarbonate as a leavening agent increases the formation of the compound. Which of the following is/are the compound? (A) Acyclovir (B) Acrylamide (C) Benzo[a]pyrene (D) Furans (E) Polychlorinated biphenyls

複選題13. Which of the following is/are the occupational exposure agent classified by International Agency for Research on Cancer (IARC) as group 1 definite human carcinogen? (A) Beryllium (B) Di(2-ethylhexyl)phthalate (C) 2-Naphthylamine (D) Soot (E) Wood dust

複選題14. Which of the following is/are NOT CORRECT about the core components of Metabolic Syndrome? (A) Increased central obesity (B) Insulin resistance (C) Decreased fasting insulin (Type 1 diabetes) (D) Increased blood urea nitrogen and creatinine levels (E) Increased serum triglycerides and hypertension

複選題15. Regarding to the nuclear receptor coactivators which statement(s) is (are) CORRECT? (A) The coactivator might contain the histone acetyl transferase (HAT) domain (B) The coactivator may contain the RNA binding domain (C) The mechanisms and activity could be the tissue-specificity to hormone-responses. (D) The coactivators are unique and specific to a specific nuclear receptor. (E) The co-activator might contribute to the regulation of gene expression.

17. What are the paired colors to show the colocalization of two fluorescent probes or two pseudo- colors in a specimen? (A) Alexa Fluor 488 and Cy3: orange and yellow (B) eGFR and DsRed: Blue (C) Blue and Red: Magenta (D) Blue and Green: Cyan (E) Green and Red: Yellow

複選題18. Regarding to the high throughput techniques and the "Omics", which pairs are CORRECT? (A) RNA-seq: Transcriptomics (B) Bisulfite sequencing: Epigenetics (C) Image-based high content analysis (HCA): Cytomics (D) LC-MS/MS: Proteomics (E) Q-PCR: Phosphoproteomics

複選題19. Regarding to the statements of the onco-immunology (IO), which are CORRECT? (A) PD1/PDL1 is the immune checkpoint pathway (B) Antibody to stimulate the PD1 has shown the therapeutic benefit for cancer patients (C) Activation or up-regulation of PDL1 in tumor cells could inhibit the T-cell activation (D) Lower level of PDL1 in tumor tissues might show the better outcome of patients with cancer immunotherapy (e.g., Pembrolizumab) (E) The adverse effects of the cancer immunotherapies include interstitial pneumonitis

複選題20. Which is (are) the RNA virus (has RNA as its genetic material)? (A) Human Papillomavirus (B) Influenza B virus (C) Severe Acute Respiratory Syndrome Coronavirus 2 (D) Hepatitis B virus (E) Human Immunodeficiency virus

複選題21. Which abbreviation of the following amino acids are CORRECT? (A) Y=Tyrosine (B) Q= Glutamic acid (C) W=Tryptophan (D) E= Aspartic acid (E) K= Lysine 

複選題22. Monoclonal antibody (mAb) is a powerful research tool and a drug for treating diseases. Regarding mAb which statements are NOT CORRECT? (A) mAb can be used to kill tumor cells or to block the binding of viruses or bacteria to host cells (B) The development and production of mAb is much cheaper than small molecule inhibitor drugs (C) Hybridoma technology is still the only way to generate mAbs (D) mAbs for immune checkpoint blockade such as CTLA-4 and PD-1 are successfully used for treating autoimmune diseases (E) mAbs can be used to target molecules located on the cell surface and inside the cells