複選題

22. Monoclonal antibody (mAb) is a powerful research tool and a drug for treating diseases. Regarding mAb which statements are NOT CORRECT?
(A) mAb can be used to kill tumor cells or to block the binding of viruses or bacteria to host cells
(B) The development and production of mAb is much cheaper than small molecule inhibitor drugs
(C) Hybridoma technology is still the only way to generate mAbs
(D) mAbs for immune checkpoint blockade such as CTLA-4 and PD-1 are successfully used for treating autoimmune diseases
(E) mAbs can be used to target molecules located on the cell surface and inside the cells

複選題18. Regarding to the high throughput techniques and the "Omics", which pairs are CORRECT? (A) RNA-seq: Transcriptomics (B) Bisulfite sequencing: Epigenetics (C) Image-based high content analysis (HCA): Cytomics (D) LC-MS/MS: Proteomics (E) Q-PCR: Phosphoproteomics

複選題19. Regarding to the statements of the onco-immunology (IO), which are CORRECT? (A) PD1/PDL1 is the immune checkpoint pathway (B) Antibody to stimulate the PD1 has shown the therapeutic benefit for cancer patients (C) Activation or up-regulation of PDL1 in tumor cells could inhibit the T-cell activation (D) Lower level of PDL1 in tumor tissues might show the better outcome of patients with cancer immunotherapy (e.g., Pembrolizumab) (E) The adverse effects of the cancer immunotherapies include interstitial pneumonitis

複選題20. Which is (are) the RNA virus (has RNA as its genetic material)? (A) Human Papillomavirus (B) Influenza B virus (C) Severe Acute Respiratory Syndrome Coronavirus 2 (D) Hepatitis B virus (E) Human Immunodeficiency virus

複選題21. Which abbreviation of the following amino acids are CORRECT? (A) Y=Tyrosine (B) Q= Glutamic acid (C) W=Tryptophan (D) E= Aspartic acid (E) K= Lysine 

複選題23. Mitochondria are the power plant of the cells that produce ATP for maintain cell homeostasis. Other than bioenergy what else do mitochondria do in the cells. (A) Regulate signal transduction (B) Regulate apoptosis (C) Regulate the functions of immune cells (D) Regulate reactive oxygen species (E) Regulate metabolism

24. CRISPR-Cas9 is a breakthrough of technology for genome editing. Which statements regarding CRISPR-Cas9 are NOT CORRECT? (A) Cas9 is an RNAse originally identified in bacteria (B) CRISPR sequences can be served as a guide to recognize and cleave specific strands of DNA (C) The mechanism of CRISPR-Cas9-meidated genome editing is working through dsDNA break and induced repair system in the host cells (D) CRISPR-Cas9 can only be used to generate knockout mice but not knockin mice (E) CRISPR-Cas9 can target multiple genes at a time

複選題25. Regarding reverse transcriptase, which statements are NOT CORRECT? (A) It has DNA-dependent RNA polymerase activity (B) It has RNA-dependent DNA polymerase activity (C) It is an important enzyme for doing polymerase chain reaction (PCR) (D) It has no proof-reading activity and therefore is error-prone (E) It was originally identified in Adenovirus

複選題26. Molecules involved in cell cycle controls cell growth. Which statements regarding cell cycle are CORRECT? (A) There are 5 different phases, namely G0, G1, S, G2, and M (B) DNA content in both G2 and M phase is twice as much as G1 (C) There are two major checkpoints namely G1/S and G2/M checkpoints which ensure that everything is ready for DNA synthesis and mitosis, respectively (D) CDK is inactive in the absence of cyclin (E) DNA damage-induced cell cycle arrest is due to the induction of p53 and its downstream genes such as CDK inhibitors.

複選題27. Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Which of the following statements regarding signal transduction are CORRECT? (A) Intracellular signals can be triggered by proteins with enzymetic activity such as kinases or phosphatases (B) Proteins can be phosphorylated at histidine, tyrosine or serine residues (C) Adaptor proteins usually undergo phosphorylation and provide a docking sites for other signal mediators (D) Src homology domain 2 (SH2) binds to proline-rich containing proteins (E) Calcium is a well-known second messenger

28. Apoptosis is a programmed cell death that plays a key role in physiology and pathology. Which statements regarding apoptosis is NOT CORRECT? (A) Starvation is a trigger for the extrinsic pathway of apoptosis (B) Bcl2 is anti-apoptotic molecule in intrinsic pathway of apoptosis (C) Caspase 3 is the initiator caspase for both intrinsic and extrinsic pathways of apoptosis (D) Cytochrome c release from mitochondria is a hallmark for intrinsic pathway (E) Apoptotic cells will be rapidly engulfed by macrophages and induce inflammation