1. 關於早期small cell lung cancer，下列敘述那些正確？ (a) 只有不到5%的小細胞癌診斷為stage 1 (b) T1~2N0M0可以考慮手術切除 (c) 即使早期手術完整切除後仍需接受術後輔助治療 (d) 術後輔助治療可以考慮加prophylactic cranial irradiation
(A) a+b+c
(B) a+b+c+d
(C) a+b
(D) b+c+d

32. In eukaryotic cells, chromosomes are composed of (A) DNA (B) RNA (C) Phospholipid (D) Ribosome (E) Protein

複選題33. Viruses? (A) Make their own ATP, proteins, and nucleic acids (B) Have RNA rather than DNA (C) Use the host cell to copy themselves and make viral proteins (D) That infect bacteria called phage (E) Enveloped viruses have a phospholipid membrane outside their capsid, whereas nonenveloped viruses do not have a phospholipid membrane

34. Which of the following statements is a correct distinction between autotrophs and heterotrophs? (A) Cellular respiration is unique to heterotrophs (B) Only heterotrophs have mitochondria (C) Autotrophs, but not heterotrophs, can nourish themselves beginning with CO2 and other nutrients that are inorganic (D) The most common way that autotrophs make their own food is converting inorganic molecules into usable components by sunlight through photosynthesis (E) Only heterotrophs require oxygen

複選題35. Which of the following scientists were responsible for the following discovery? (A) Erwin Chargaff discovered that in DNA from any species, the amount of adenine equals the amount of thymine, and the amount of guanine equals the amount of cytosine (B) Alfred Hershey and Martha Chase discovered that RNA can be converted to DNA by reverse transcription (C) James Watson and Francis Crick discovered that DNA is a double helix in structure (D) Oswald Avery, Maclyn McCarty, and Colin MacLeod discovered that DNA is genetic material (E) Matthew Meselson and Franklin Stahl discovered that DNA replication is semi- conservative

2. 對於轉移性肺腫瘤手術切除適應症，下列何者錯誤？ (A) 原發處需要己被或可被控制 (B) 無其他肺外轉移 (C) 肺部轉移處可完整手術切除 (D) 雙側都有則不建議手術

3. 胸腔鏡式肺葉切除應用於肺癌，以下何者不是目前較被認同的適應症？ (A) peripheral location (B) size ＜ 6cm (C) No chest wall invasion (D) Endobronchial lesion

4. 關於早期肺癌，下列敘述何者錯誤？ (A) Bronchioalveolar carcinoma (BAC) 可視為adenocarcinoma的一種subtype (B) Atypical Adenomatous Hyperplasia (AAH) 可視為preneoplastic lesion (C) 大部份BAC在正子攝影上顯影為弱或不表現 (D) BAC常會由淋巴轉移

5. 關於Bronchioalveolar carcinoma (BAC)，下列敘述何者錯誤？ (A) 可分成3型:mucinous/nonmucinous/mixed type (B) Nonmucinous BAC常表現thyroid transcription factor-1 (TTF-1) (C) Mucinous BAC則較常有CK20或CK7表現 (D) BAC常見stromal invasion及pleural invasion

6. 關於肺腺癌gene mutation，下列敘述何者錯誤？ (A) 有無EGFR mutation可預測對Gefitinib的藥物反應 (B) 在東方不吸菸女性肺腺癌患者EGFR mutation比例最高 (C) EGFR exon 20 deletion or exon 21 L858R deletion是最常見的突變處 (D) K-ras mutation通常也與Gefitinib藥物抗性有關

7. 關於肺癌組織免疫染色，下列敘述何者錯誤？ (A) TTF-1在原發性肺腺癌大部份會表現，轉移性肺癌則不表現 (B) CK7及CK20可用來區分大腸癌肺轉移 (C) CDX2可用來區分腸胃道癌肺轉移 (D) 肺部腫瘤如CK7(+)及CK20(+)則較傾向是大腸癌肺轉移