10. A patient is diagnosed with a rare mutation that impairs the ability of intracellular receptors to dimerize upon hormone binding. Which of the following hormonal responses would be most severely affected? (A) insulin-mediated glucose uptake in muscle cells (B) epinephrine-induced glycogen breakdown in hepatocytes (C) cortisol-induced transcriptional activation in target tissues (D) parathyroid hormone (PTH)-induced calcium mobilization (E) growth hormone (GH)-induced IGF-1 secretion from the liver