12. The protein which marks proteins for degradation is called .
(A) Chaperonin
(B) Ubiquitin
(C) Proteosomin
(D) Apoptosin
(E) adenosine

8. The following: (1). histone acetylation； (2). H3K4me (histone3 lysine4 methylation)； (3).H3K9me (histone3 lysine9 methylation)； (4).H3K27me (histone 3 lysine 27 methylation)； (5). DNA methylation； (6). HDAC (histone deacetylase)； (7). HAT (histone acetyltransferase). Which are related to gene activation? (A) (1), (2) and (7) (B) (1), (3), (4) and (6) (C) (1), (2), (3), (4), (5) and (6) (D) (3), (4), (5) and (6) (E) (1) and (7)

9. In prokaryotes, protein synthesis rates are limited by the rates of mRNA synthesis. RNA synthesis occurs at about 60 nucleotides/sec. Therefore, protein synthesis occurs at about amino acids/sec. (A) 10 (B) 15 (C) 20 (D) 30 (E) 60

10. Which is incorrect about transcription activators (or sequence-specific DNA-binding proteins) in eukaryotic cells? (A) They contain DNA-binding domain and activation domain. (B) They bind to enhancers. (C) They interact with Mediators through activation domain. (D) Their binding elements need to next to promoter for recruit RNA polymerase. (E) They play key roles in control the transcription rate.

11. Which one is the product of cytosine deamination? (A) Adenine (B) Guanine (C) Inosine (D) Xanthine (E) Uracil

13. Which one is NOT a programmed cell death? (A) Apoptosis (B) Necroptosis (C) Necrosis (D) Pyroptosis (E) Phagoptosis

複選題14. The central dogma does not include (A) DNA replication (B) RNA transcription (C) Protein translation (D) Reverse transcription (E) Lysine sumoylation

15. Which one is NOT an unfolded protein response? (A) endocytosis (B) Increase chaperon protein expression (C) Promote protein degradation (D) Induce apoptosis (E) Autophagy

16. Indicate which process NOT requires membrane fusion? (A) Insulin-mediated blood glucose homeostasis (B) Virus infection (C) Cholesterol endocytosis (D) Brain computation (E) Muscle contraction induced by nerve stimulation

17. Indicate where is neurotransmitter stored? (A) ER (B) Golgi (C) presynaptic endosome (D) Synaptic vesicle (E) presynaptic mitochondria

18. Indicate which organelles are mainly involved in protein N-glycosylation? (1). Nucleus (2). ER (3). Golgi (4). Mitochondria (5). Endosome (A) (1), (2) (B) (1), (3) (C) (3), (4) (D) (4), (5) (E) (1), (5)