試題詳解

26. Which of the following statements about the etiology and treatment of Rheumatoid Arthritis (RA) is incorrect?
(A) The efficacy of biologic DMARDs (Disease-Modifying Antirheumatic Drugs) in RA treatment is primarily due to their ability to replace damaged joint tissues through regenerative mechanisms.
(B) Epigenetic modifications, such as DNA methylation and histone modifications, play a significant role in the pathogenesis of Rheumatoid Arthritis by influencing gene expression related to immune response.
(C) The presence of specific autoantibodies, such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs), is a key diagnostic marker and plays a role in the pathogenesis of RA.
(D) Environmental factors such as smoking and obesity are known to increase the risk of developing RA and can exacerbate the severity of the disease.
(E) Gut microbiota dysbiosis has been implicated in the pathogenesis of RA, with certain bacterial species potentially triggering or exacerbating the autoimmune response.