37. Which of the following best explains how proteasomal and lysosomal degradation differ in substrate specificity and regulation? (A) Both systems rely on molecular chaperones, but only lysosomes degrade non-protein cellular components such as lipids. (B) Lysosomes selectively degrade misfolded proteins through autophagy, while proteasomes degrade native proteins marked for turnover. (C) Proteasomes degrade extracellular and cytosolic proteins, while lysosomes are restricted to extracellular material. (D) Proteasomal activity is regulated by lysosomal enzymes, ensuring coordinated protein turnover. (E) Proteasomal degradation requires substrate ubiquitination and ATP hydrolysis, while lysosomal degradation is ubiquitin-independent and primarily pH-dependent.