43. During the mitotic phase, the enzyme separase is responsible for cleaving the cohesin proteins that hold sister chromatids together, a step crucial for the initiation of anaphase. If a cell possesseda dominant mutation causing separase to be constitutively active and begin cleaving all cohesins prematurely during prometaphase (before the M checkpoint criteria were met), which outcome is the most likely and immediate consequence?
(A) The resulting daughter cells would skip the G1 phase and immediately enter the S phase due to premature activation of maturation-promoting factor (MPF).
(B) The cell would successfully complete mitosis, but the spindle poles would fail to move apart due to inactive non-kinetochore microtubules.
(C) The M checkpoint would fall, and the liberated chromatids would segregate randomly, resulting in genetically unequal daughter cells.
(D) The nuclear envelope would reform immediately, triggering early telophase and preventing the remaining spindle microtubules from attaching to kinetochores.
(E) Cytokinesis would initiate during prophase, leading to the formation of multiple, small nuclei within a single parent cell.