45. A mutation in the vasopressin receptor V2 (V2R) leads to a loss of function in the renal collecting ducts. Which of the following is the most likely clinical manifestation? (A) Production of hyperosmotic urine due to an increased insertion of aquaporin-2 (AQP2) in the lumenal surface of the collecting duct cells. (B) The excessive water retention by unregulated vasopressin signaling results in hypertension. (C) Impaired water reabsorption in the collecting ducts leads to polyuria with hypoosmotic urine. (D) Compensatory increase in aldosterone secretion that enhances sodium reabsorption in the proximal tubule. (E) Enhanced renin-angiotensin system activation leads to the eventual increase in plasma volume.