阿摩線上測驗
56.下列因素何者是酒精造成acetaminophen對肝毒性更高的原因？
(A)glutathione存量下降
(B)抑制CYP2E1的活性
(C)抑制CYP2D6的活性
(D)抑制CYP3A4的活性
答案：登入後查看
統計： A(4489), B(1253), C(415), D(610), E(0) #1632262
統計： A(4489), B(1253), C(415), D(610), E(0) #1632262
詳解 (共 7 筆)
Chung Shun Lin
#3481364
但酒精增加Acetaminophen的肝毒性有另外一個pathway喔!
ethanol會induce CYP2E1使得acetaminophen更容易代謝成NAPQI
73
0
tracy73926
#2594425
Acetaminophen的quinone化物可和肝中的glutathione結合而解毒；
如果glutathione存量下降，則quinone化物和S-H結合，可能造成肝腎壞死，低血糖性昏迷
40
2
joker
#2471774
資料來源: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014937/
Although the possibility remains that chronic consumption of alcohol does increase the risk of paracetamol hepatotoxicity in man (perhaps by impairing glutathione synthesis), there is insufficient evidence to support the alleged major toxic interaction.
21
3
