63. Which of the following statements about thymidylate synthase is correct?

① It catalyzes the conversion of dUMP and N5 , -methylene-tetrafolate to dTMP and dihydrofolate. 

② It catalyzes the conversion of dUDP and N5 , -methylene-tetrafolate to dTDP and dihydrofolate. 

③ It catalyzes the conversion of dUMP and N5 , -methylene-tetrafolate to dTMP and tetrahydrofolate. 

④ 5-Fluorodeoxyuridine monophosphate acts as an irreversible inhibitor of thymidylate synthase.

⑤ 5-Fluorouracil is a reversible inhibitor of thymidylate synthase.
(A) ①④
(B) ①⑤
(C) ②④
(D) ②⑤
(E) ③④

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統計: A(4), B(1), C(2), D(1), E(2) #3429742

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