65. An enzyme-catalyzed reaction was carried out with the substrate concentration initially a thousand times greater than the Km for that substrate. After 9 minutes, 1% of the substrate had been converted to product, and the amount of product formed in the reaction mixture was 12 µmol. If, in a separate experiment, one-third as much enzyme and twice as much substrate had been combined, how long would it take for the same amount (12 µmol) of product to be formed? (A) 1.5 minutes (B) 13.5 minutes (C) 27 minutes (D) 3 minutes (E) 6 minutes