阿摩線上測驗
79.王先生67歲，75公斤，無藥物過敏史，口服藥慢性處方箋如下：metformin 500 mg BID；omeprazole 20 mg
QD；atorvastatin 20 mg QD；amlodipine 5 mg QD。新增處方ledipasvir 90 mg/sofosbuvir 400 mg（Harvoni®） QD PO。下列敘述何者正確？
(A)此處方無疑義，可進行調劑
(B)此處方有重複用藥問題
(C)omeprazole與Harvoni®有交互作用
(D)amlodipine劑量過高
答案：登入後查看
統計： A(877), B(103), C(2451), D(42), E(0) #2865437
統計： A(877), B(103), C(2451), D(42), E(0) #2865437
詳解 (共 5 筆)
粗暴言論duck不必
#5541952
ledipasvir 90 mg/sofosbuvir 400 mg（Harvoni®）
Ledipasvir inhibits HCV NS5A protein
sofosbuvir inhibits NS5B RNA-dependent RNA polymerase
慢性C型肝炎病毒（hepatitis C virus, HCV）基因型1、4、5或6
72
0
serotonin_donor
#5565283
Micromedex DDI
Severity: major
Mechanism: loss of ledipasvir solubility due to increased pH
Interaction effect: decreased ledipasvir exposure and loss of efficacy
Management: If concurrent use is required, give PPI and Harvoni at the same time, under fasted conditions, and at a dose comparable to omeprazole 20 mg/day or lower.
13
0