⑴Angiotensin converting enzyme inhibitor / Bradykinin B2 receptor

二、請說明與腸泌素（incretin）相關的兩類口服降血糖藥之作用機轉並各舉一例藥品。 （20 分）

三、以 Gentamicin 治療腎功能正常的感染病人，靜脈給藥後其血漿半衰期約 2-3 小時， 但臨床上卻可見使用 once daily 方式給藥：⑴請說明此治療方式之原理，⑵此類藥 品治療時常見的副作用為何？應如何預防或監測？（20 分）

⑴須檢測病人那些細胞接受體之表現來決定其治療策略，

⑵常 見的荷爾蒙治療藥品及標靶用藥請各舉一例。（20 分）

⑵Carbamazepine / HLA-B*1502 allele

⑶Digoxin / P-glycoprotein 3435TT genotype

⑷Mercaptopurine / Thiopurine methyltransferase polymorphism

⑸Clarithromycin / KCNE2 variants in potassium channels

⑴Before you start filing, Mr. Doe, the CEO of ABC, wonders whether this improved medication is a non-statutory subject matter for an invention patent according to our Patent Act? Please provide your legal analysis in English with regard to this matter.（20 分）

⑵Mr. Doe acknowledges that, due to the outbreak of SARS (severe acute respiratory syndrome) and H1N1 pandemics occurred several years ago, the R.O.C. became the first country to issue a compulsory licensing for Tamiflu, an imported medication used to treat the H1N1 virus. Mr. Doe wonders on what grounds can our government issue a compulsory licensing? Please provide your legal advice in English with regard to this matter.（20 分）