⑸Clarithromycin / KCNE2 variants in potassium channels

⑴Angiotensin converting enzyme inhibitor / Bradykinin B2 receptor

⑵Carbamazepine / HLA-B*1502 allele

⑶Digoxin / P-glycoprotein 3435TT genotype

⑷Mercaptopurine / Thiopurine methyltransferase polymorphism

⑴Before you start filing, Mr. Doe, the CEO of ABC, wonders whether this improved medication is a non-statutory subject matter for an invention patent according to our Patent Act? Please provide your legal analysis in English with regard to this matter.（20 分）

⑵Mr. Doe acknowledges that, due to the outbreak of SARS (severe acute respiratory syndrome) and H1N1 pandemics occurred several years ago, the R.O.C. became the first country to issue a compulsory licensing for Tamiflu, an imported medication used to treat the H1N1 virus. Mr. Doe wonders on what grounds can our government issue a compulsory licensing? Please provide your legal advice in English with regard to this matter.（20 分）

二、Please translate the following provision into English.（10 分） 專利法規定，發明專利申請人對於申請案公開後，曾經以書面通知發明專利申請內 容，而於通知後公告前就該發明仍繼續為商業上實施之人，得於發明專利申請案公 告後，請求適當之補償金。

【已刪除】⑴一個二次離散系統之系統函數為 。請畫出 H (z ) 的第一類直  接形式（direct form 1）與平行（parallel）架構之方塊圖。（10 分）

⑵若 H (z ) 之收斂區（region of convergence）為¼

二、一個低通濾波器之截止頻率（cutoff frequency）為 wc ，頻率轉換函數（transfer function）為Hlp(w)，脈衝響應為hlp[n]。請轉換低通濾波為鏡式（mirror）高通濾波 器，並列出鏡式高通濾波器頻率響應函數Hhp(w)與脈衝響應hhp[n]之轉換公式。（ 20 分）