複選題

10. Which of the following is/are NOT the protein(s) produced by fat cells under direction of the ob gene that can decrease appetite and increase energy expenditure?
(A) Adiponectin
(B) Biotin
(C) Fatty acid-binding protein
(D) Klotho
(E) Leptin 

複選題6. Choose the descriptions which are NOT CORRECT: (A) DNA methylation on the promoter region is commonly associated with downregulation of gene expression. (B) Promoter is a region at the gene where the transcriptional machinery binds. (C) Enhancers are the units of regulatory sequences which spread thousands of nucleotides from only the upstream of promoter. (D) Insulators are found between enhancers and some promoters to block activation of the promoter by activators. (E) The function of histone acetyl transferases is adding acetyl groups to histones tails, allowing the histones to wrap the DNA more tightly.

複選題7. Which of the following descriptions about Apoptosis are CORRECT? (A) It is a kind of programmed cell death in response to extracellular or intracellular stresses. (B) Cells swell and form apoptotic body at the end of apoptosis. (C) There are external and internal pathways in apoptotic signal transduction, and both activation processes converge to a common protein, caspase 9, to finally induce apoptosis. (D) DNA is cleaved into small fragments with around 180 to 200 bp in size. (E) Both apoptosis and autophagy share most of the regulatory mechanisms.

複選題8. Which of the following descriptions for metal or heavy metal exposure is/are CORRECT? (A) Blood and urine concentrations usually are reflective of more recent exposures and correlate with acute adverse effects (B) Hair can be useful in assessing variations in exposure to metals over the period of its growth (C) The biological half-lives of arsenic in bone are 20--30 years (D) The half-life of lead in blood is only a few weeks (E) After inhalation of mercury vapor, at least two half-lives describe the retention in brain

複選題9. Which of the following unit of the radiation activity is/are CORRECT? (A) The units of measurement for radioactivity are the becquerel (Bq, international unit) and the curie (Ci, U.S. unit) (B) The unit used for effective dose is sievert (Sv, international unit) or rem (U.S. unit) (C) A millisievert is one hundred of a sievert (D) The unit for absorbed dose is the gray (Gy, international unit) or the rad (U.S. unit) (E) One gray is defined as 1 joule of energy released in 1 g of tissue

複選題11. Which of the following environment pollutants are endocrine-disrupting chemicals? (A) Bisphenol A (B) Benzo(a)pyrene (C) ẞ-naphthoflavone (D) Polychlorinated biphenyls (E) 2,3,7,8-tetrachlorodibenzo-p-dioxin

複選題12. The compound is/are formed in foods that are high in carbohydrate, but low in protein, which are subjected to processing temperatures of at least 120°C. The presence of ammonium bicarbonate as a leavening agent increases the formation of the compound. Which of the following is/are the compound? (A) Acyclovir (B) Acrylamide (C) Benzo[a]pyrene (D) Furans (E) Polychlorinated biphenyls

複選題13. Which of the following is/are the occupational exposure agent classified by International Agency for Research on Cancer (IARC) as group 1 definite human carcinogen? (A) Beryllium (B) Di(2-ethylhexyl)phthalate (C) 2-Naphthylamine (D) Soot (E) Wood dust

複選題14. Which of the following is/are NOT CORRECT about the core components of Metabolic Syndrome? (A) Increased central obesity (B) Insulin resistance (C) Decreased fasting insulin (Type 1 diabetes) (D) Increased blood urea nitrogen and creatinine levels (E) Increased serum triglycerides and hypertension

複選題15. Regarding to the nuclear receptor coactivators which statement(s) is (are) CORRECT? (A) The coactivator might contain the histone acetyl transferase (HAT) domain (B) The coactivator may contain the RNA binding domain (C) The mechanisms and activity could be the tissue-specificity to hormone-responses. (D) The coactivators are unique and specific to a specific nuclear receptor. (E) The co-activator might contribute to the regulation of gene expression.

複選題16. Regarding to the applications of fluorescence labbeled monoclonal antibody which statement(s) is (are) CORRECT? (A) To isolate sub-population of cells via flow cytometry  (B) To identify specific RNA expression via real time Q-PCR (C) To identify specific protein for immunofluorescence (IF) image. (D) To quantify the protein level via Western blotting (E) To identify a specific DNA adduct