試題詳解

複選題
57. Which statements accurately describe the physiological activity of eicosanoids in the arachidonic acid pathway?
(A) Corticosteroids inhibit phospholipase A2, resulting in decreased levels of prostaglandins, thromboxanes, and leukotrienes.
(B) Leukotrienes (LT) promotes the contraction of smooth muscle, contraction of airway, trachea, and small intestine, and increascs microvascular permeability, leading to edema.
(C) Rofecoxib, a selective COX-II inhibitor, was withdrawn from the market due to its concurrent production of thromboxane while generating PGI2, resulting in myocardial infarction.
(D) PGE2 (Prostaglandin E2) is commonly used as a labor-inducing agent in clinical practice mainly because it promotes the contraction of uterine smooth muscles, thereby initiating uterine contractions and facilitating the progression of labor.