16. Which of the following is NOT a feature of apoptosis?
(A) formation of apoptotic body
(B) DNA fragmentation
(C) cell swelling
(D) activation of caspases
(E) release of cytochrome C from mitochondria

The correct answer is **(C) cell swelling**.

### Explanation:

**Apoptosis**, also known as programmed cell death, is a controlled and orderly process that eliminates cells without causing damage to surrounding tissue. Key features of apoptosis include:

- **(A) Formation of apoptotic bodies**: During apoptosis, the cell breaks apart into small, membrane-bound vesicles called apoptotic bodies, which are then cleared by phagocytes.

- **(B) DNA fragmentation**: One of the hallmark features of apoptosis is the fragmentation of the cell’s DNA into smaller, more manageable pieces, which can then be efficiently cleared.

- **(D) Activation of caspases**: Caspases are proteases that play a central role in apoptosis. They are activated in response to apoptotic signals and lead to the breakdown of key cellular components.

- **(E) Release of cytochrome C from mitochondria**: In many apoptotic pathways, cytochrome C is released from the mitochondria, which triggers the activation of caspases and the initiation of the apoptotic cascade.

However, **(C) Cell swelling** is typically associated with **necrosis**, not apoptosis. In necrosis, cells swell and rupture, often leading to inflammation, whereas in apoptosis, cells shrink and undergo a controlled breakdown without swelling.

Therefore, **cell swelling** is not a feature of apoptosis.